Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1991-04-15
1994-05-10
Stoll, Robert L.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
523375, A61K 4900, A61K 4902
Patent
active
053105397
ABSTRACT:
The present invention involves an image-enhancing agent comprising melanin combined with an essentially non-dissociable signal-inducing metal. The signal-inducing metal has an association constant for its melanin combination of at least about 10.sup.20. Upon suspension or dissolution in water the metal remains undissociated. A preferred signal-inducing metal is paramagnetic or superparamagnetic, of course for magnetic resonance imaging. A preferred paramagnetic or superparamagnetic metals are gadolinium, iron, nickel, copper, erbium, europium, praseodymium, dysprosium, holmium, chromium or manganese. Gadolinium is the most effective metal. The metal is incorporated into the melanin in an ionic or particulate form. Metals may be utilized which are particularly useful to modify ultrasound images by the enhancement of the image obtained from emission and detection of high-frequency soundwaves. Metals emitting gamma particles may also be utilized to enhance images resulting from gamma particle emission scanning. .sup.51 Chromium, .sup.68 gallium, .sup.99m technitium and .sup.111 indium are preferred metals for gamma particle scanning. Additionally, native or synthesized melanin, in and of itself is an effective MRI image-enhancing agent.
REFERENCES:
patent: 4247406 (1981-01-01), Widder et al.
patent: 4352751 (1982-10-01), Wieder
patent: 4370476 (1983-01-01), Usher
patent: 4421671 (1983-12-01), Cusano
patent: 4423158 (1983-12-01), Porath
patent: 4432907 (1984-02-01), Wieder
patent: 4452773 (1984-06-01), Molday
patent: 4472509 (1984-09-01), Gansow
patent: 4639365 (1987-01-01), Sherry
patent: 4647447 (1987-03-01), Gries et al.
patent: 4698374 (1987-10-01), Gallas
patent: 4731239 (1988-03-01), Gordon
patent: 4735210 (1988-04-01), Goldenberg
patent: 4735796 (1988-04-01), Gordon
patent: 4770183 (1988-09-01), Groman et al.
patent: 4822594 (1989-04-01), Gibby
patent: 4904479 (1990-02-01), Illum
patent: 4957939 (1990-09-01), Gries et al.
patent: 4963344 (1990-10-01), Gries et al.
patent: 4968980 (1991-01-01), Jacobsen
patent: 4985233 (1991-01-01), Klaveness et al.
patent: 5021236 (1991-06-01), Gries et al.
patent: 5057302 (1991-10-01), Johnson et al.
patent: 5137711 (1992-08-01), Weber et al.
patent: 5185368 (1993-02-01), Peter et al.
patent: 5187207 (1993-02-01), Gallas et al.
Monograph No. 5629, Merck Index, p. 5632, 10th Edition, 1983.
Aime et al. "NMR Studies of L-Dopa Melanin-Manganese (II) Complex in Water," Journal of Inorganic Biochemistry, 36(1), 1989, pp. 1-9.
Lauffer et al., "Preparation and Water Relaxation Properties of Proteins Labeled with Paramagnetic Metal Chelates," Magnetic Resonance Imaging, vol. 3, No. 1, 1985, pp. 11-16.
Ishiwata et al., "Feasibility Study of Fluorine-18 Labeled Dopa for Melanoma Imaging," Abstract No. 111705p, Nucl. Med. Biol., 16(4):371-4, (1989). File Server STN, Karlsruhe DE, File Chemical Abstracts, vol. 111, No. 13, published in Columbus, Ohio, USA.
Dawson et al., "Progress Toward the Synthesis of Polymerically Bound Chelating Agents for Iron(III) and the Development of a New Assay Method for Determining Iron Chelator Effectiveness," Development of Iron Chelators for Clinical Use, pp. 201-209 (1981).
Dialog Search Report, 97 pages (23 Jun. 1990).
Brasch et al., "Contrast-Enhanced NMR Imaging: Animal Studies Using Gadolinium-DTPA Complex," A.J.R., 142:625-30 (1984).
Buonocore, et al., "Potential Organ Specific MRI Constrast Agents for Liver and Spleen: Gadolinium Labelled Liposomes," Proc. Soc. Mag. Resonance in Med., 838-839 (1985).
Burnett et al., "Gadolinium Oxide: A Prototype Agent for Contrast Enhanced Imaging of the Liver and Spleen with Magnetic Resonance," Magnetic Resonance Imaging, 3:65-71 (1985).
Chen et al., "Paramagnetic Metalloprophyrins as Potential Contrast Agents in NMR Imaging,," Fed. Euro. Biochem. Soc., 168(1):70 (1984).
Desreux, "Nuclear Magnetic Resonance Spectroscopy of Lanthanide Complexes with a Tetraacetic Tetraaza Macrocycle. Unusual Conformation Properties," Inorganic Chemistry, 19:1319-24 (1980).
Enochs et al., "Sources of the Increased Longitudinal Relaxation Rates Observed in Melanotic Melanoma. An in vitro Study of Synthetic Melamins.," Invest. Radiol., 24(10):794-804, (Oct. 1989).
Geraldes et al., "Magnetic Field Dependence of Solvent Proton Relaxation Rates Induced by Gd.sup.3+ Complexes of Various Polyaza Macrocyclic Ligands: Implications for NMR Imaging," Magnetic Resonance in Medicine, 3:242-50 (1986).
Goldstein et al., "Gadolinium DTPA (An NMR Proton Imaging Contrast Agent): Chemical Structure, Paramagnetic Properties and Pharmacokinetics," Physiol. Chem. & Phys. & Med. NMR, 16:97-104 (1984).
Hintz et al., "Metal Ion-induced Activation of Molecular Oxygen in Pigmented Polymers," Biochim. Biophys. Acta, 883:41-45 (Aug. 6, 1986).
Lettvin et al., "Gd(TTHA): An aqueous Carbon-13 Relaxation Reagent," J. Mag. Res., 28:459-61 (1977).
Martell, A., "The Design and Synthesis of Chelating Agents," Development of Iron Chelators for Clinical Use, pp. 67-104 91981).
Mirowitz et al., AJK Am. J. Roentgenol, 154, 369-73 (Feb. 1990).
Runge, et al., "Work in Progress: Potential Oral and Intravenous Paramagnetic NMR Contrast Agents," Radiol., 147:789-91, (Jun. 1983).
Sarna et al., "Ion Exchange in Melanin: An Electron Spin Resonance Study with Lanthanide Probes," Science, 192:1132-4, (Jun. 11, 1976).
Weinmann et al., "Characteristics of Gadolinium-DTPA Complex: A Potential NMR Contrast Agent," A.J.R., 142:619-24 (1984).
Wolf, "Contrast Enhancement in Biomedical NMR," Physiol. Chem. & Phys. & Med. NMR, 16:93-95 (1984).
Board of Regents , The University of Texas System
Chapman Lara E.
Stoll Robert L.
LandOfFree
Melanin-based agents for image enhancement does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Melanin-based agents for image enhancement, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Melanin-based agents for image enhancement will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2411530