Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-05-10
2005-05-10
Slobodyansky, Elizabeth (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S252300, C435S254110, C435S320100, C435S325000, C530S350000, C536S023500
Reexamination Certificate
active
06890733
ABSTRACT:
The present invention relates to a novel protein of the MEKK signal transduction pathway, and the gene encoding it. The invention further relates to diagnostic and therapeutic uses of the protein or the gene, and to methods of screening for agonists or antagonists of the protein, particularly with respect to MEKK activity. In particular, the invention provides a gene encoding MIF1, the MIF1 protein, and antibodies that specifically bind MIF1. MIF1 and the MIF1 gene can be used in screening assays, particularly to identify agonists and antagonists of MIF1 interaction with MEKK, and thus modulators of the MEKK signal pathway. MIF1 gene (or cDNA) can also be delivered to cells, e.g., for in vitro screening or testing, or in vivo or ex vivo for gene therapy.
REFERENCES:
Ren et al. (Sep. 10, 1997) GenBank accession AF015308 (human).*
Ren et al. (Sep. 10, 1997) GenBank accession AF015309 (mouse).*
Bruni et al. Herpes Simplex Virus 1 Regulatory Protein ICP22 Interacts with a New Cell Cycle-Regulated Factor and accumulates in a Cell Cycle-Dependent Fashion in Infected Cells. J. Virol. 72(11):8525-8531, Nov. 1998.
Ren et al. “The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120” Eur. J. Biochem. 253(3):734-742 (May 1, 1998).
Marcireau Christophe
Multon Marie-Christine
Polard-Housset Valerie
Aventis Pharma S.A.
Slobodyansky Elizabeth
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