Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1994-10-14
1998-12-29
Teng, Sally P.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
435 691, 530350, C07K 14435, C12N 912
Patent
active
058540431
ABSTRACT:
The present invention relates to isolated MEKK proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to use such proteins to regulate signal transduction in a cell. The present invention also includes therapeutic compositions comprising such proteins or nucleic acid molecules that encode such proteins and their use to treat animals having medical disorders including cancer, inflammation, neurological disorders, autoimmune diseases, allergic reactions, and hormone-related diseases. When MEKK is expressed, it phosphorylates and activates MEKs including MEK-1, MEK-2 and JEK.
REFERENCES:
Seger et al., J. Biol. Chem., vol. 267, 25628, 1992.
Wang et al., Molecular and Cellular Biology, vol. 11, 3554, 1991.
Dent et al., pp. 1404-1407, 1992, Science, vol. 257.
Kolch et al., "Raf-1 Protein Kinase is Required for Growth of Induced NIH/3T3 Cells", pp. 426-428, 1991, Nature, vol. 349, Jan. 31.
Kyriakis et al., pp. 417-421, 1992, Nature, vol. 358.
L'Allemain et. al., "p42/Mitogen-Activated Protein Kinase as a Converging Target for Different Growth Factor Signaling Pathways: Use of Pertussis Toxin as a Discrimination Factor", pp. 675-684, 1991, Cell Reg., vol. 2, Aug.
Leberer et. al., "The Protein Kinase Homologue Ste20p is Required to Link the Yeast Pheromone Response G-protein .beta..gamma. Subunits to Downstream Signalling Components", pp. 4815-4824, 1992, EMBO J., vol. 11.
Qureshi et. al., "An Inhibitory Mutant of c-Raf-1 Blocks v-Src-induced Activation of the Egr-1 Promoter", pp. 20594-20597, 1991, J. Biol. Chem., vol. 226, No. 31, Nov.
Stevenson et. al., "Constritctive Mutants of the Protein Kinase STE11 Activate the Yeast Pheromone Response Pathway in the Absence of the G Protein", pp. 1293-1304, 1992, Genes & Dev., vol. 6.
Tamaki et. al., "Surface Immunoglobulin-mediated Signal Transduction Involves Rapid Phosphorylation and Activation of the Protooncogene Product Raf-1 in Human B-Cells", pp. 566-570, 1992, Cancer Res., vol. 52, Feb. 1.
DeConti, Jr. Giulio A.
Kara Catherine J.
National Jewish Center for Immunology and Respiratory Medicine
Teng Sally P.
LandOfFree
MEKK-related signal transduction kinases does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with MEKK-related signal transduction kinases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and MEKK-related signal transduction kinases will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1423676