Meiotic recombination in vivo of partially homologous DNA...

Details Meiotic recombination in vivo of partially homologous DNA... Meiotic recombination in vivo of partially homologous DNA...

2006-10-03

2006-10-03

Woitach, Joseph (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C536S023100, C536S023400, C435S320100, C435S254200

Reexamination Certificate

active

07115413

ABSTRACT:
Process for the meiotic recombination in vivo of partially homologous DNA sequences having up to 30% of base mis-matches, wherein eukaryotic cells containing the sequences and in which an enzymatic mismatch repair system is defective, are maintained under conditions to effect meiosis. Preferably the enzymatic mismatch repair systems of the eukaryotic cells are defective by virtue of at least one mutS protein and/or at least one mutL protein being defective or missing. The eukaryotic cells may be unicellular organisms such as yeasts.

REFERENCES:
patent: 90 07576 (1990-07-01), None
Thomas, “Advances in the genetics and molecular biology of colorectal tumors”, Curr. Opin. Oncol., 6(4):406-412.
Reitmair et al. ‘MSH2 deficient mice . . . ’ Nat Genet 11(1):64-70 (Sep. 1995).
Edelmann et al. ‘Meiotic Pachytene arest . . . ’ Cell 85:1125-1134 (1996).
Santucci-Darmanin et al. ‘MSH4 acts in conjunction . . . ’ FASEB J 14:1539-1547 (2000).
Lipkin et al. ‘Meiotic arrest and . . . ’ Nature Genetics 31:385-390 (Aug. 2002).
Moens et al. ‘The time course and chromosomal . . . ’ J cell Sci 115:1611-1622 (2002).
E. Alani et al., “Interaction between mismatch repair and genetic recombination in saccharomyces cerevisiae”, Genetics, vol. 137, No. 1, pp. 19-39, May 1994.
T.A. Prolla et al., “Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1: two homologs of the bacterial mutl gene”, Molecular and Cellular Biology, vol. 14, No. 1, pp. 407-415, Jan. 1994.
E.M. Selva et al., “Mismatch correction acts as a barrier to homologous recombination in saccharomyces cerevisiae”, Genetics, vol. 139, No. 3, pp. 1175-1188, Mar. 1, 1995.
N. Hunter et al., “The mismatch repair system contributes to meiotic sterility in an interspecific yeast hybrid”, Embo Journal, vol. 15, No. 7, pp. 1726-1733, Apr. 1, 1996.
S.R. Chambers et al., “The mismatch repair system reduces meiotic homologous recombination and stimulates recombination-dependent chromosome loss”, Molecular and Cellular Biology, vol. 16, No. 11, pp. 6110-6120, Nov. 1996.

Affiliated with

Also associated with

Rating

Meiotic recombination in vivo of partially homologous DNA... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Meiotic recombination in vivo of partially homologous DNA..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Meiotic recombination in vivo of partially homologous DNA... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3679826