Megakaryocyte differentiation factor

Details Megakaryocyte differentiation factor Megakaryocyte differentiation factor

1996-03-06

1999-10-26

Allen, Marianne P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 530350, 530351, 530395, C07K 1452, A61K 3818, A61K 3819, C12N 1512

Patent

active

059728868

ABSTRACT:
A novel megakaryocyte differentiation factor, for example, consisting essentially of SEQ ID NO: 30; DNA coding for the megakaryocyte differentiation factor, an expression vector comprising the DNA, a host transformed with the expression vector, and a process for production of the megakaryocyte differentiation factor using the host.
The megakaryocyte differentiation factor accelerates differentiation of megakaryocytes in the presence of IL-3, and acts as a thrombopoietin, and therefore an effective medicament to various diseases involving a decrease in platelete.

REFERENCES:
Chemical Abstracts 113: 22039y, vol. 113, 1990.
H. Mizoguchi: Tanpakushitsu Kakusan Koso, 36, 1195-1201, 1991.
T. Matsuda et al.: Tanpakushitsu Kakusan Koso, 36, 1184-1194, 1991.
N. Yamaguchi et al.: "Characterization of New Human Pancreatic Cancer Cell Lines Which Propagate in a Protein-free Chemically Defined Medium," Cancer Res., 50, 7008-7014, 1990.

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