Medium chain fatty acids of C8-10 for the treatment of skin lesi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514859, 514863, A61K 3120

Patent

active

051751909

ABSTRACT:
This invention pertains to the use of medium chain fatty acids (C8-10) in the treatment of skin lesions. More particularly, the invention relates to a preparation containing medium chain fatty acids (C8-10) which has beneficial effects when applied topically in skin conditions, including acne, psoriasis, chronic conditions considered to be pre-cancerous lesions, and malignant lesions of skin. A composition for topically treating skin lesions which comprises a fatty acid of a carbon number from 8 to 10 having a free carboxyl group and a pharmaceutically acceptable carrier.

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R. W. Turnell and A. F. Burton, "Glucorticoid Receptors and lymphocytolysis in normal and neoplastic lymphocytes", Molecular & Cellular Biochemistry, 9, 175-189 (1975).
A. F. Burton and L. H. Piette, "Spin labelling studies of cytolysis induced by fatty acids", Molecular & Cellular Biochemistry, 51, 73-78 (1983).
A. F. Burton and W. L. Dunn, "Role of anions in the lymphocytolytic action of corticosteroids and fatty acids", Molecular & Cellular Biochemistry 63, 125-129 (1984).
A. F. Burton, J. M. Storr and W. L. Dunn, "Cytolytic action of corticosteroids on thymus and lymphoma cells in vitro", Canadian Journal of Biochemistry 45, 289-297 (1967).
Chemical Abstracts 98: 113737n (1983).
Francoeur et al --Pharmaceutical Research, vol. 7, No. 6 (1990).

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