Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Patent
1987-12-23
1990-02-06
Sneed, H. M. S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
514687, 514734, 514885, C07O31160
Patent
active
048988901
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to medicines for use in the therapy and prevention of kidney and liver diseases, and more particularly to medicines of this kind which can exhibit excellent therapeutic and preventive effects with respect to kidney or liver diseases individually developed or to complications resulting from diseases of these organs.
BACKGROUND ART
As is well known, the kidney in a vital organism performs at its renal tubule and with its filtration and secretion mechanism the function of excreting into the urine waste substances from blood and noxious substances taken up by the vital organism, such as drugs and toxic substances.
On the other hand, the liver in a vital organism performs three major functions, as listed below. Namely, the liver first acts as a digestive gland and secretes 500 to 1000 cc of bile per day to assist in the digestion and absorption of fats by the small intestines. Its second function is to process chemical changes, storage, and use of various nutrients within the body; in brief, it is an intermediate metabolism. Thirdly, the liver performs detoxication by subjecting noxious substances, such as toxin, from outside the body and toxic substances produced within the body, to detoxication treatments such as oxidization, reduction and inclusion, and by mixing these substances with bile to dispose of them or by sending them to the kidney for excretion into the urine.
In this way, although the kidney and the liver perform their individual functions, the above-mentioned waste substances and drugs tend to accumulate locally, and therefore these substances often cause kidney diseases and liver diseases to develop, not only individually but also as complications resulting from diseases of these organs. Specific substances which can cause such individual or complicated kidney and liver diseases are of various types. For instance, drugs which can act as such substances are listed below and are classified according to the organs to be affected. In the following list, the drugs marked with the symbol are those which can cause injury to both the kidney and the liver.
Drugs possessing the tendency to cause kidney injury
Analgestics, antipyretics, anti-inflammatory drugs, and antirheumatic drugs: compounds, D-penicillamine, etc.
Antibiotics:
Chemotherapeutic drugs:
Anti-cancer drugs:
Immunosuppressants:
Anesthetics:
Diuretics:
Contrast media
Drugs possessing the tendency to cause liver injury
Analgestics, antipyretics, anti-inflammatory drugs, and antirheumatic drugs: etc.
Antibiotics: etc.
Chemotherapeutic agents:
Anti-cancer drugs:
Anesthetics:
Psychotropic drugs:
Diuretics:
The above-listed examples of drugs which can cause kidney and liver diseases are arranged in order based on the following publications:
RINSHOH SEIJINBYOH (Clinical Studies of Adult Diseases), No.8, vol, 16, (1986), pages 45 to 62 and 85 to 103; SAISHIN IGAKU BUNKO, 42 "Mansei Kan'en no Shinryoh (Diagnosis and Treatment of Chronic Hepatitis)" by Mikio Nishioka, published by Shinkoh Igaku Shuppan-sha K.K. on January 26, 1987, pages 29 to 31; RINSHOH TO KENKYUH (Clinical Studies), No. 4, vol. 63 (published in Apr. 1986), pages 38 to 39; KANZOH NO BYOHKI (Liver Diseases), by Toshitsugu Orita et al, published by Chuhgai Igaku-sha on October 20, 1980, pages 323 to 333; and IYAKUHIN YOHRAN (Handbook of Medical Articles), edited by Osaka-Fu Byohin Yakuzaishi-Kai, published by Yakugyo Jihoh Sha on Nov. 10, 1983.
Hereinabove, kidney and liver diseases have been discussed from the viewpoint of the metabolic functions of these organs. However, some kidney diseases are considered to be caused by the intermediary of the immunological mechanism.
Kidney diseases specified herein are the following: (a) a functional disorder of the kidney which is caused by abnormality in the above-mentioned metabolic functions, including acute hepatitis caused by drugs, etc., and chronic nephritis developed from such acute nephritis; (b) acute nephritis caused by the intermediary of the immunological mechanism and chronic
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File WPIL, No. 88-165728, Derwent Publications Ltd., London, GB; and JP-A-63 104 920 (Tsumura Juntendo K.K.) 10-05-88.
Kakegawa Hisao
Matsumoto Hitoshi
Sato Toshio
Dainippon Ink and Chemicals Inc.
Nippon Hypox Laboratories Incorporated
Saba J.
Sneed H. M. S.
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