Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-09-06
2005-09-06
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C536S023100, C536S024300, C536S024330
Reexamination Certificate
active
06939674
ABSTRACT:
Correlations between polymorphisms in the 5-lipoxygenase gene, or polymorphisms in the leukotriene C4 synthase gene, and a subject's phenotypic response to treatment with a leukotriene receptor antagonist for respiratory disease are described. Methods of screening subjects to aid in treatment, and methods of screening therapeutic compounds, are presented.
REFERENCES:
patent: 6334099 (2001-12-01), Grace et al.
patent: WO 97/42347 (1997-11-01), None
patent: WO 99/10529 (1999-03-01), None
Silverman et al. Pharmacogenetics of the 5′ lipoxygenase Pathway in Asthma et al. Clinical and Experimental Allergy, 1998, vol. 28, Supplemental 5, pp. 164-170, 1998.
Calhoun, “Anti-leukotrienes for asthma,”Current Opinion in Pharmacology1(3):230-234 (Jun. 2001).
Drazen et al., “Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment,”Nature Genetics22(2):168-170 (Jun. 1999).
In et al., “Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription,”Journal of Clinical Investigation99(5):1130-1137 (1997).
Sanak et al., “Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma,”Lancet350(9091):1599-1600 (Nov. 1997).
Silverman et al., “Pharmacogenetics of the 5-lipoxygenase pathway in asthma,”Clinical and Experimental Allergy28(Suppl. 5):164-170 (Nov. 1998).
Anderson Wayne H.
Edwards Lisa D.
Emmett Amanda H.
Pillai Sreekumar
Sprankle Catherine S.
Campen Virginia G.
Horlick Kenneth R.
SmithKline Beecham Corporation
Wilder Cynthia
LandOfFree
Medicine response assay in respiratory disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Medicine response assay in respiratory disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Medicine response assay in respiratory disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3442133