Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Patent
1994-10-28
1996-10-29
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
514 34, 514274, 514316, A61K 3324, A61K 3170, A61K 31505, A61K 31445
Patent
active
055694713
ABSTRACT:
A medicine for the treatment of tumor. The medicine contains 4-piperidino-piperidine or a physiologically acceptable salt thereof as the effective component. Although 4-piperidino-piperidine or a physiologically acceptable salt thereof do not exhibit tumor cell killing effect per se, they suppress propagation of tumor cells, dissolve resistance of other antitumor drugs, and enhance the antitumor activity of antitumor drugs. Therefore, when the medicine according to the present invention is used in combination with other antitumor drugs, their inherent antitumor activity is enhanced. Since the dose of antitumor drugs which are to be used along with the medicine of the present invention can be reduced, adverse side effects are reduced.
REFERENCES:
Chemical Abstracts, vol. 116, No. 1, 6 Jan. 1992, Columbus, Ohio, US; abstract No. 118h, "Studies on the metabolic fate of CPT-11 (3). Pharmacokinetics in rats following a single intravenous administration of cpt-11 (PP)." p. 8; * abstract * & Yakubutsu Dotai, vol. 6, No. 1, 1991, pp. 105-125.
Derwent Publications Ltd., London, GB; AN 88-202979 & JP-A-63 141 964 (Koei Chem. Ind. KK.) 1988. * abstract *.
Toxicol. Appl. Pharmacol., vol. 40, No. 1, 1977, pp. 147-159, "T-Lymphocyte depletion and Lesion of choroid plexus and kidney induced by tertiary amines in rats." * p. 148, fig. 1, compound No. 10 * * p. 147 *.
Int. J. Cancer, vol. 50, No. 4, 1992, pp. 604-610, "Effects of CPT-11 in combination with other anti-cancer agents in culture." * p. 606, Left column-paragraph 5 * * p. 606, right column, paragraph 2 *.
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