Medicinal preparations

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides

Reexamination Certificate

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C300S013000

Reexamination Certificate

active

07067618

ABSTRACT:
The present invention provides a pharmaceutical preparation comprising a compound which can be obtained by reacting a compound having a free amino group with a sugar having the reducing power. The preparation is capable of improving the in vivo durability of various compounds and releasing the compounds in response to changes in pH, and thus is useful for causing the compounds to act specifically on target parts.

REFERENCES:
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patent: 5723121 (1998-03-01), Takenaga et al.
patent: 07-061999 (1995-07-01), None
patent: 09-263579 (1997-07-01), None
patent: WO9003401 (1990-04-01), None
patent: WO9601639 (1996-01-01), None
patent: WO9823625 (1998-06-01), None
Stedman's Medical Dictionary, 1995, Williams and Wilkins, Baltimore. p. 1223, col. 1, Lines 61-64.
G. Wilson, “Effect Of Reductive Lactosamination On The Hepatic Uptake Of Bovine Pancreatic Ribonuclease A Dimer”, vol. 253, No. 7, Apr. 10, 1978, pp. 2070-2072.
Inoue, et al., “Synthesis Of A Superoxide Dismutase Derivative That Circulates Bound To Albumin And Accumulates In Tissues Whose pH Is Decreased”, Biochemistry 1989, 28, 6619-6624.
Patent Abstracts of Japan, Pub. No. 07-061999, pub. Jul. 3, 1995.
Patent Abstracts of Japan, Pub. No. 09-263579, pub. Jul. 10, 1997.
Rogers, et al., “Hepatic Uptake Of Proteins Coupled To Fetuin Glycopeptide”, vol. 45, No. 3, 1971, pp. 622-629.
Schmer, et al., “Kinetics Of Uptake And Activity In Mouse Liver Of Glutaminase Coupled To Desialated Orosomucoid”, 538 (1978), pp. 397-405.
Fiume, et al., “Lactosaminated Human Serum Albumin As Hepatotropic Drug Carrier”, vol. 146, No. 1, Sep. 1982, pp. 42-46.
Fiume et al., “A Chemically Stable Conjugate Of 9-β-D-Arabinofuranosyl-Adenine 5′-Monophosphate With Lactosaminated Albumin Accomplishes A Selective Delivery Of The Drug To Liver Cells”, vol. 35, No. 6, pp. 967-972, 1986.
Marsh, et al., “Glycosylation OfEscherichia coliL-Asparaginase”, vol. 252, No. 21, pp. 7678-7684, 1977.
G. Wilson, “Effect Of Reductive Lactosamination, On The Hepatic Uptake Of Bovine Pancreatic Ribonuclease A Dimer”, vol. 253, No. 7, Apr. 10, 1978, pp. 2070-2072.

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