Medicinal emulsions

Details Medicinal emulsions Medicinal emulsions

1993-03-09

1994-11-15

Kishore, G. S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 514937, 514938, 514939, 514943, A61K 9127, B01J 1302

Patent

active

053646320

ABSTRACT:
A pharmaceutical composition being an oil in water type emulsion which comprises an effective amount of a lypophilic drug is provided. The composition comprises a synergistic combination consisting of about 3-50% of an oily carrier consisting of MCT oil optionally in combination with vegetable oil, about 0.05%-20% of a phospholipid, about 0.03-10% of a non-ionic surfactant, and about 0.05-5% of an ionic surfactant selected from the group consisting of bile-duct surface active agent, cholic acid and their derivatives.

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patent: 4914088 (1990-04-01), Glonek et al.
Benita et al. Internet. J. Pharmeceut. 30, p. 47, 1986.
Rompp Chemie Lexikon, 9th Edition, p. 1343, item "Fettsauren," Georg Thieme erlag, Stuttgart (1990).
Hardberger, R., "Effects of Drug Vehicles on Ocular Contact Time", 93:42-45 (1975).
Patent Abstracts of Japan, vol. 5, No. 200, 18th Dec. 1981, p. 102 C 84; & JP-A-56 122 309.
Enhanced Stability of Physostigmine Salicylate in Submicron O/W Emulsion-Yashwant V. Pathak, et al., 1990, Intl. Journal of Pharmaceutics, 65 (1990) 169-175.

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