Medicinal compositions and method for the preparation thereof

Details Medicinal compositions and method for the preparation thereof Medicinal compositions and method for the preparation thereof

2004-12-10

2009-10-06

Richter, Johann R (Department: 1619)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

C424S489000, C514S772100, C523S200000

Reexamination Certificate

active

07597897

ABSTRACT:
Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible polymer of the general formula —[O—R1—C(O)]n— wherein: “R1” is a linear, branched, or cyclic organic group, “n” is at least three, (b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride; (c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water, (d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid; and (e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.

REFERENCES:
patent: 5041529 (1991-08-01), Shinoda et al.
patent: 5302693 (1994-04-01), Stricker et al.
patent: 5569450 (1996-10-01), Duan et al.
patent: 5618911 (1997-04-01), Kimura et al.
patent: 5714618 (1998-02-01), Kimura et al.
patent: 5871771 (1999-02-01), Zierenberg et al.
patent: 6111033 (2000-08-01), Loughman et al.
patent: 6126919 (2000-10-01), Stefely et al.
patent: 6264970 (2001-07-01), Hata et al.
patent: 6416742 (2002-07-01), Stefely et al.
patent: 2002/0164290 (2002-11-01), Stefely et al.
patent: 2002/0173496 (2002-11-01), Biggadike
patent: 2004/0247561 (2004-12-01), Seo et al.
patent: 2004/0253195 (2004-12-01), Seo et al.
patent: 9059218 (1997-03-01), None
patent: 9124778 (1997-05-01), None
patent: WO 94/21229 (1994-09-01), None
patent: WO 03/033592 (2003-04-01), None
patent: WO 03/033593 (2003-04-01), None
H. Fukazaki et al., “Synthesis of Copoly (D,L-Lactic Acid) with Relatively Low Molecular Weight and In Vitro Degradation,”Eur. Polym. J., 25, 1019-1026 (1989).
A. Carrio et al., “Preparation and degradation of surfactant-free PLAGA microsphere,”J. Controlled Release, 37, 113-121 (1995).
P.P. DeLuca et al., “Biodegradable Polyesters for Drug and Polypeptide Delivery,”Polymeric Delivery Systems; ACS; Chapter 4, 53-77 (1993).
B. Wichert et al., “Low molecular weight PLA: a suitable polymer for pulmonary administered microparticles?”.J. Microencapsulation, 10, 195-207 (1993).
J.W. Tom et al., Precipitation of Poly(L-lactic acid) and Composite Poly(L-lactic acid)-Pyrene Particles by Rapid Expansion of Supercritical Solutions;J. Supercritical Fluids, 7, 9-29 (1994).
R. Wada et al., “New.biodegradable oligoesters for pharmaceutical application,”J. Biomater Sci., Polym. Ed., 7, 715-725 (1996).
M. Dittrich, “Purification of biodegradable polymers and oligomers of aliphatic hydroxyl acids”, Abstract of Czech Patent No. CZ 278181 (Sep. 15, 1993) Abstract only: CA122(16):188468y.
D. Duan et al., “Oligomeric Lactic Acids as Solubilizing Aids for HFA-Based Metered Dose Inhalers,” Biomaterials Technology Center, 3M Corporation, 3M Pharmaceuticals, (Nov. 1998).
D. Duan et al., “Novel Dispersing Aids for Hydrofluoroalkane-Based Metered Dose Inhalers,” Biomaterials Technology Center, 3M Corporation, 3M Pharmaceuticals (Nov. 1998).
C. Leach et al., “Metabolism, Distribution, and Toxicity of Oligomeric Lactic Acids Used in Pulmonary Drug Delivery,” Biomaterials Technology Center, 3M Corporation, 3M Pharmaceuticals, (Nov. 1998).
J. Stefely et al., “Design and Utility of a Novel Class of Biocompatible Excipients for HFA-Based MDIs,” Respiratory Drug Delivery VII, Palm Harbor at Tarpon Springs, FL, 5/14-18, 2000.

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