Medicinal compositions

Details Medicinal compositions Medicinal compositions

2005-04-26

2005-04-26

Solola, Taofiq (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C514S789000

Reexamination Certificate

active

06884768

ABSTRACT:
The present invention provides a medicinal composition comprising (1) a pharmacologically active substance, (2) a drug absorbefacient and (3) a taurine compound or a polyamine. A taurine compound has an efect of suppressing or preventing damage of the intestinal mucous membrane, and therefore adding the taurine compound to a medicinal composition containing a pharmacologically active substance and a drug absorbefacient makes it possible to suppress or prevent damage of the intestinal mucosa. A polyamine improves the absorbability of pharmacologically active substances, and therefore adding the polyamine to a medicinal composition containing a pharmacologically active substance and a drug absorbefacient makes it possible to decrease the dose of the drug absorbefacient, thereby suppressing or preventing damage of the intestinal mucosa.

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Miwon Son et al., Protective Effect of Taurine on Indomethacin-induce Gastric Mucosal Injury, Arch. Parm. Res., 1996, vol. 19, No. 2, pp. 85 to 90.
Toshikiro Kimura et al., Electrophysiological Approach to the Action of Taurine on Rat Gastric Mucosa, j. Pharm. Dyn., 1982, vol. 5, pp. 495 to 00.
Katsuhiro UDA, “Rat Shocho ex vivo deno Glucose Kyushu ni taisuru Polyamine no Zokyo Koka” Digestion & Absorption, 2000, vol. 23, No. 1, pp. 28-30.

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