Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1989-06-14
1992-05-26
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514930, A61K 31135
Patent
active
051168782
ABSTRACT:
This medicinal composition for the treatment and prevention of the symptoms of heart failure contains, by way of active principle, at least one compound chosen from 2-amino-1-(2,5-dimethoxyphenyl)-1-propanol (methoxamine) and its pharmaceutically acceptable salts, and it is presented in a form which can be administered by inhalation (aerosol or nebulizate).
It was demonstrated, in particular, that the administration of methoxamine-HCl by inhalation, at a unit dosage of 10 mg, in the form of a 2% (w/v) solution in physiological saline, decreases airways resistance in subjects suffering from decompensated left ventricular failure, and increases the exertion tolerance of patients suffering from compensated left vetricular failure, whether the latter is of ischemic origin or otherwise.
REFERENCES:
patent: 2359707 (1944-10-01), Baltzly et al.
patent: 3787571 (1974-01-01), Higuchi
patent: 3891757 (1975-06-01), Higuchi
patent: 3968245 (1976-07-01), Higuchi
patent: 4080471 (1978-03-01), Carlsson et al.
patent: 4083992 (1978-04-01), Smith
patent: 4853216 (1989-08-01), Koslo et al.
Pharmaceutical Dispensing, Third Edition (1947) Husa pp. 312-319; Husa Brothers, Iowa City, Iowa.
The Handbook of Nonprescription Drugs, 8th edition, American Pharmaceutical Association, Publisher, copyright 1986 pp. 172-173.
L. Cabanes et al., "Bronchial Hyperresponsiveness to Methacholine in Patients with Impaired Left Ventricular Function", published May 18, 1989 The New England Journal of Medicine, 320(20), pp. 1317-1322.
Cabanes Laure
Lockhart Alain
Weber Simon
Henley III Raymond J.
Universite de Paris V
Waddell Frederick E.
LandOfFree
Medicinal composition for the treatment and prevention of the sy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Medicinal composition for the treatment and prevention of the sy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Medicinal composition for the treatment and prevention of the sy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-420438