Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1982-06-09
1985-03-19
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
A61K 970, A61L 1503, A61F 1300
Patent
active
045058911
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to medicinal adhesive sheets usable for the medical treatment and prevention of heart diseases. More particularly, the present invention relates to medicinal adhesive sheets containing nitroglycerin for heart diseases as the principal ingredient.
BACKGROUND ART
Nitroglycerin has long been used for the internal treatment of ischemic heart diseases. Nitroglycerin has been administered in the form of various preparations such as intravenous injection, sublingual tablets and ointments. The duration of the effects of intravenous injections, sublingual tablets and ointments are several minutes, 20-30 minutes and 3-5 hours, respectively.
Generally, sublingual tablets are used for the treatment of angina pectoris. However, their effects are short lived, and the sublingual tablets are therefore unsuitable for preventing an attach.
A nitroglycerin-containing ointment is used when the effects of nitroglycerin are to be maintained for a long period of time (for example, in preventing angina pectoris). When ointment is used, a suitable amount of the ointment is applied to the skin of the patient's chest and is then covered with a plastic film or the like and to prevent the volatilization of the nitroglycerin and staining of his clothes. The suitable amount of ointment is an amount slightly smaller than that which causes a headache. The ointment is applied in various amounts to the respective patients to determine the proper amount experimentally. At present, the amount of ointment is estimated from the length of the bead extruded from the tube, so determination of the precise quantity of the ointment is difficult. Further, the use of ointment is troublesome as described above.
(Prior Arts)
Recently, medicinal adhesive sheets containing nitroglycerin have been proposed (see the specification of Japanese Patent Laid-Open No. 2604/1980). However, the nitroglycerin retention and release of the sheets are unsatisfactory, since the adhesive contained therein has not been improved (an adhesive plaster base is used).
Copolymers of alkyl acrylates or alkyl methacrylates in which the alkyl group contains 4-12 carbon atoms have generally been used as adhesives only slightly irritating the skin. However, these conventional adhesives have a high ability to adsorb nitroglycerin and, therefore, a low nitroglycerin-releasing property. Thus, they are unsuitable for use as a carrier for nitroglycerin which is to be released as an active ingredient.
(Object of the Invention)
After investigations on adhesives having only a slight irritating effect on the skin and an excellent nitroglycerin-releasing property made under the above circumstances, the inventors have accomplished the present invention and the object has been attained.
DISCLOSURE OF THE INVENTION
(Construction of the Invention)
The object of the present invention has been attained by using a new copolymer developed by the inventors as an adhesive of an adhesive composition for medicinal adhesive sheets for heart diseases. The new copolymer is obtained by copolymerizing:
(a) about 60-98 parts by weight of dodecyl methacrylate,
(b) about 2-40 parts by weight of a functional monomer, and
(c) about 0-40 parts by weight of at least one short chain unsaturated monomer selected from the group consisting of vinyl acetate, alkyl acrylates in which the alkyl group contains 1-8 carbon atoms and alkyl methacrylates in which the alkyl group contains 1-8 carbon atoms.
In the present invention, the medicinal adhesive sheet for heart diseases is prepared by applying an adhesive composition containing the above copolymer and a suitable amount of nitroglycerin as the essential ingredient to a suitable base.
The description will be made on the constituents of the present invention.
(Copolymer)
(a) The suitable amount of dodecyl methacrylate constituting the copolymer according to the present invention is about 60-98 parts by weight as described above, and, more preferably, about 70-95 parts by weight.
(b) Suitable functional monomer
REFERENCES:
patent: 4420470 (1983-12-01), Otsuka et al.
patent: 4421737 (1983-12-01), Ito et al.
Nichiban Co. Ltd.
Nippon Kayaku Kabushiki Kaisha
Rose Shep K.
Taiho Pharmaceutical Company Limited
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