Medicinal adhesive for percutaneous administration

Details Medicinal adhesive for percutaneous administration Medicinal adhesive for percutaneous administration

1994-04-01

1996-04-09

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, A61F 1300

Patent

active

055059562

ABSTRACT:
Disclosed herein is a medicinal adhesive for percutaneous administration of a drug consisting of a support (backing layer), an adhesive layer comprising an oil-soluble drug, an adhesive resin, a penetration enhancer, a water-absorptive material and a lenitive agent, and a separate liner, charaterized in that the adhesive layer has a laminated structure having 2 to 5 layers and each layer has different water absorption capacities, and the drug is a oil-soluble, non-steroidal drug. For the adhesive of the present invention, the lowest layer which is to be contacted with the skin has the lowest water absorption capacity and the most upper layer in contact with the support has the highest water absorption capacity, or vice versa.

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E. R. Cooper, "Increase Skin Permeability . . . " Jour. of Pharmaceutical Science, vol. 73 No. 8 Aug. 1984, pp. 1153-1156.
D. Patel et al, "Comparative study of propylene glycol . . . " Journal of the Society of Cosmetic Chemists, 36 (Jul./Aug. 1985), pp. 303-311.

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