Medicated chewing-gum

Details Medicated chewing-gum Medicated chewing-gum

1997-01-29

2003-03-25

Zeman, Mary K. (Department: 1631)

Drug, bio-affecting and body treating compositions

Chewing gum type

C424S440000, C424S441000, C424S634000, C514S399000, C514S406000

Reexamination Certificate

active

06537525

ABSTRACT:

BACKGROUND OF THE INVENTION
One of the most common gastrointestinal ailments to afflict modern man is gastroesophageal reflux disease (GERD). GERD includes such symptoms as heartburn, indigestion, sour stomach, dyspepsia and flatulent dyspepsia. The frequency of the occurrences of GERD is difficult to estimate, but it is reasonable to assume that a majority of individuals living in industrialized societies today suffer from it at one time or another. Dietary indiscretion appears on the surface to be the primary cause along with stress, but GERD actually has a multifactorial etiology. The extent of the problem is evidenced by the multitude of prescription and non-prescription remedies available to the sufferer and the billions of dollars spent annually on treatments for GERD.
Multiple factors contribute to the occurrence of GERD. These factors include: efficacy of the anti-reflux mechanism; volume of gastric fluid; potency of the refluxed material; efficiency of esophageal clearance; and tissue resistance of the esophageal mucosa. The extent and severity of reflux esophagitis depends not on gastroesophageal reflux alone, but also upon the volume of gastric juice available to reflux, the potency of the refluxed material, the interval that the refluxed material remains in the esophagus, and the ability of the esophageal tissue to withstand injury and to repair itself after injury.
Currently, treatments available over the counter, i.e. without a prescription from a physician, include antacid preparations, anti-gas preparations, combination antacid and anti-gas preparations, and bismuth containing compounds. More recently, histamine H-2 receptor antagonists, which are now available over the counter, and proton pump inhibitors, which are not currently available over the counter, have added substantially to the treatment armamentarium. However, none of these preparations addresses the multifactorial etiology of gastroesophageal reflux disease. Thus, a need has developed in the art for a composition for the treatment of GERD which addresses that multifactorial etiology.


REFERENCES:
patent: 4139589 (1979-02-01), Beringer et al.
patent: 4647450 (1987-03-01), Peters
patent: 4971787 (1990-11-01), Cherukuri
patent: 5294433 (1994-03-01), Singer et al.
patent: 5364616 (1994-11-01), Singer et al.
patent: 5552163 (1996-09-01), Hartman et al.
patent: 5562936 (1996-10-01), Song et al.
patent: 5567450 (1996-10-01), Zuromski et al.
patent: 5599577 (1997-02-01), Stevens et al.
patent: 322 048 (1992-06-01), None
patent: 349 103 (1992-11-01), None
patent: 92/17161 (1992-10-01), None
patent: 95/05173 (1995-02-01), None
Drug Facts and Comparisons 1996 Wolters Kluwer, St. Louis. Chapter 7, p 1824-1891, Jan. 1996.*
Physician's Desk Reference for Non Prescription Drugs 17th ed. 1996 p. 799.
Consumer's Digest Mar./Apr. 1997 p. 71.
Abstracts of Papers, May 1980, p. 1181
Archs oral Biol. vol. 38, No. 10, pp. 885-891, 1993.
Archs oral Biol. vol. 40, No. 8, pp. 699-705, 1995.
Caries Res 1992;26:176-182.
Abstract, Pharm. Res. 1992 Feb. 9(2), p. 255-9.
Abstract, Caries Res. 1992 26(3), p. 176-82.
Environmental Nutrition, Nov. 1995 v18 n11 p. 3(1).
Facts on file, Dec. 21, 1995, p. 957.
FDA Consumer, 1995 (remainder of citation unknown).
Gastroenterology 75: 275-77, 1978.
Gastroenterology 1981; 81:376-94.
Gastroenterology, vol. 108, No. 4, p. A204.
Harrison's Principles of Internal Medicine, Chap. 314, p. 1447-48.
HealthFacts, Jun. 1995 v20 n193, p. 2(1).
Industry Week, Jan. 8, 1996 v245, p. 14.
J. Clin. Invest 65: 256-267 (Feb. 1980).
Pharmaceutical Research, vol. 9, No. 2, pp. 255-259, 1992.
Pharmazie 1992 47 (8):607-9.
Physician's Desk Reference, 50th ed. 1996:529-30, 2562-63.
Scand J. Dent Res. 1993: 101: 386-390.
Bockus Gastroenterology, 5th ed. 1995, Chapter 34.

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