Medicaments potentiated with phenyl alkanols

Details Medicaments potentiated with phenyl alkanols Medicaments potentiated with phenyl alkanols

1981-11-20

1984-10-02

Rosen, Sam

Drug, bio-affecting and body treating compositions

Combustible or chemically reactive to produce a smoke, mist...

424 80, 424 50, 424177, 424181, 424227, 424235, 424244, 424250, 424251, 424263, 424273R, 424274, 424283, 424285, 424287, 424322, 424324, 424326, 424329, 424343, A61K 972, A61K 31175

Patent

active

044747489

ABSTRACT:
Antimicrobial compositions are provided wherein there is obtained an enhancement of activity by combining the antimicrobial agent with an effective amount of a potentiator. The potentiator is selected from the group consisting of a primary, secondary and tertiary phenylalkanol, halophenylalkanol or C.sub.1 to C.sub.3 alkylphenylalkanol where the alkanol has from about 3 to about 9 carbon atoms.
The compositions comprising an antimicrobial agent and a potentiating agent are useful as surgical scrub solutions and in dressing topical wounds where the presence of blood and wound exudate would otherwise inhibit the action of the antimicrobial agent if it were to be used alone.
Also provided are topically active compositions wherein topical activity of a medicament is enhanced by combining the medicament with an effective amount of a potentiator as defined above. The topical compositions are useful as topical anesthetics, cell regulatory agents, antimicrobials, anti-inflammatory compositions, and the like.

REFERENCES:
patent: 3502594 (1970-03-01), Ahrens
Richards et al.-Chem. Abst., vol. 78 (1973), p. 47774f.
Richards et al.-Chem. Abst., vol. 80 (1974), p. 66969f, (Orig. Article 1973).
McCulloch et al.-Chem. Abst., vol. 65 (1966), p. 10997c.
Lal et al.-Chem. Abst., vol. 62 (1965), p. 14417g.
Hiromichi-Chem. Abst., vol. 48 (1954), p. 14094c.
Kotzbauer-Chem. Abst., vol. 69 (1968), p. 30125m.
Gnarpe et al.-Chem. Abst., vol. 69 (1968), p. 104,088a.

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