Medicaments for the treatment of papillomavirus diseases

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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536 2372, 536 241, 530300, 530350, C12Q 168, C07H 1700, C07K 1400

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active

059255161

ABSTRACT:
Medicaments, and methods of identifying the same, are described that are useful for treating papillomavirus diseases that have the characteristics of preventing, interfering with, or reversing the binding of the appropriate papillomavirus proteins E1 or E2 to a nucleotide sequence homologous to a nucleotide sequence present in the papillomavirus genome, or of the formation of a complex consisting of papillomavirus proteins E1 and E2, or the binding of the complex to the nucleotide sequence.

REFERENCES:
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Chiang et al. "An E1M+E2C Fusion Protein Encoded by Human Papillomavirus Type 11 Is a Sequence-Specific Transcription Repressor"(1991) J. Virol. 65(6):3317-3329.
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Sekine et al. "Expression of human papillomavirus type 6b E2 gene product with DNA-binding activity in insect (Bombyx mori) cells using a baculovirus expression vector" (1988) Gene 65:187-193.
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