Medicament with a delayed release of active ingredient

Details Medicament with a delayed release of active ingredient Medicament with a delayed release of active ingredient

1987-06-29

1989-01-03

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424457, 424455, A61K 964

Patent

active

047956437

ABSTRACT:
In addition to the active ingredient, the capsules contain a nonionic surfactant consisting of a polyglycol ester or ether having hydrophilic and lipophilic portions, and an organic polymer which is capable of forming a free-flowing composition with the active ingredient and the surfactant. The essential point for the delay in release is the matching of the water-solubility of the active ingredient and the hydrophilic/lipophilic character (HLB value) of the surfactant as follows:

REFERENCES:
patent: 2990333 (1961-06-01), Graham
patent: 4428927 (1984-01-01), Ebert et al.
patent: 4450877 (1984-05-01), Walker et al.
patent: 4486412 (1984-12-01), Shah et al.
patent: 4539199 (1985-09-01), Orban et al.
patent: 4663149 (1987-05-01), Eckenhoff et al.
patent: 4681765 (1987-07-01), Guley

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