Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1977-09-21
1979-08-14
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, A61K 3700, C07C10352
Patent
active
041645715
ABSTRACT:
The present invention relates to a method of treating diseases and particularly gastroduodenal ulcers linked to an hypersecretion of gastrin, and to polypeptide amide derivatives which can be used in this method as therapeutic agents and more specifically as antagonists of the action of gastrin and related polypeptides relative to their specific biological receptors.
This method comprises administering a therapeutically effective amount of a polypeptide amide derivative of general formula: ##STR1## in which R.sub.1 represents a hydrogen atom or an acyl radical and R.sub.2 represents a substituted or unsubstituted aryl radical e.g. nitrophenyl group or dinitrophenyl group such as 2-nitrophenyl or 2-4-dinitrophenyl.
REFERENCES:
patent: 3896103 (1975-07-01), Hardy et al.
patent: 4012367 (1977-03-01), Mazur
Bonfils Serge J. E.
Dubrasquet Juliette M.
Fromageot Pierre
Girma Jean P.
Lewin Miguel
Commissariat a l''Energie Atomique
Institut National de la Sante et de la Recherche Medicale
Phillips Delbert R.
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