Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Reexamination Certificate
2000-05-23
2001-04-17
Lankford, Jr., Leon B. (Department: 1651)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
C514S925000
Reexamination Certificate
active
06217880
ABSTRACT:
TECHNICAL FIELD
The present invention relates to a medicament for treating recurrent ulcer in mouth and also relates to a medicament for the treatment of Behcet's Syndrome, which belongs to the field of traditional Chinese medicine.
BACKGROUND OF THF INVENTION
Recurrent ulcer in mouth is one kind of common stomatopathy, which is clinically characterized by solitary round or elliptic shallow aphtha occuring repeatedly in the oral mucosa. It frequently influences the patient's eating, drinking and sleeping due to severe spontaneous pain when attacking. In western medical therapy method it is treated by topically administering and orally taking vitamins B1, B2 and C simultaneously, and the serious ulcer can be treated by orally administering hormones for a short period. In traditional Chinese medical therapy the Chinese medicine prescription is determined by identifying deficient or excessive syndrome and based on causes of disease and clinical symptoms; however, few oral Chinese patent medicine preparations produced and developed in view of deficient or excessive syndrome have been found. Traditional preparations for external use, such as Xilei San(Xilei Powder), Bingpeng San(Borneol and Boraxg Powder), and oral preparations, such as Niuhuangjiedu Wan(Bovine Bezoar Toxin-resolving Pill) and Shangqing Wan (Bovine Bezoar Upper-Body-Cleaning Pill), only cure ulcer but not clear the potential cause of the disease, so that the problem of recurrence of the disease can't be solved radically.
DETAILED DESCRIPTION OF THE INVENTION
The object of the present invention is to provide a Chinese medicament which can be used for treatment of recurrent ulcer in mouth and Behcet's syndrome effectively.
The medicament of the present invention could be prepared from the following raw material herbs in weight proportions below (by weight portions):
root of Coptis chinesis
6-9
portion
Isatis root
2-5
portion
flower of Lonicera
2-5
portion
Puccoon
2-4
portion
root of dried Rehmannia
3-8
portion
bamboo leaf
3-6
portion
Corydalis bungeana
2-5
portion
Chinese wild ginger
2-4
portion
Lily bulb
2-5
portion
dried powder of snake gallbladder
0.1-0.5
portion
The medicament of the present invention could be prepared preferably by the following raw material herbs in weight proportions (by weight portions):
root of Coptis chinesis
7.5
portion
Isatis root
4.5
portion
flower of Lonicera
4.5
portion
puccoon
3
portion
root of dried Rehmannia
6
portion
bamboo leaf
4.5
portion
Corydalis bungeana
4.5
portion
Chinese wild ginger
3
portion
Lily bulb
4.5
portion
dried powder of snake gallbladder
0.3
portion
The medicament of the present invention may be prepared from the above mentioned raw material herbs in said weight proportions and, additionally, 3-8, preferably 6, weight portions of Ganoderma (
Ganoderma japonicum
) and 1-3, preferably 1.5, weight portions of thunder god vine (
Tripterygium wifordii
). The added herbs can restore health and eliminate pathogens and enhance curative effect.
The medicament of the invention may be prepared from above formulation of raw material herbs by conventional Chinese medicine preparation method into common forms, such as pills, powders, tablets, oral liquids, creams. While preparing the medicament of the invention, conventional assistant additives, such as starch, can be also added into above raw material herbs.
The medicament of the present invention may be prepared by following method:
The seven raw materials, bamboo leaf (lophatherum), root of
Coptis chinesis,
Isatis root (
Isatis tinctoria
L.), flower of lonicera (honeysuckle flower;
Lonicera japonica
Thunb),
Corydalis bungeana,
Lily bulb and root of dried Rehmannia (
Rhemannia glutinosa
), in the above mentioned portions are decocted twice with water, in which certain amount of water is added until the surface of the raw material herbs is just submerged each time. Two decoction liquids obtained above are combined, and then filtered to yield filter liquor
1
. Chinese wild ginger (
Asarum sieboldii; Asarum hetrotropoids manshuricum
) in the said portions is extracted with water by a common extraction method, volatile oil is collected for later use and then the decoction liquid is combined with the filter liquor
1
, and concentrated into an extractum which specific gravity may be 1.35. The extractum is added with 90-95% ethanol. The ethanol solution is concentrated whiling recovering ethanol and dried at 45-50 ° C. to yield dried extractum
1
. Puccoon (Purple gromwell) in said portions is extracted with 90-95% ethanol under reflux, and the extracted liquor is concentrated while recovering ethanol and dried at 45-50° C. to obtain dried extractum
2
. Dried extractum
2
is combined with dried extractum
1
, and then grinded into powder. Into the powder yielded the dried powder of the snake gallbladder with the said weight proportion is added, and then further grinded into fine powder. The common assistant additives is added into said fine powder. The mixture of the assistant additives and said fine powder are prepared into granule, dried, sprayed with the volatile oil of Chinese wild ginger obtained above, and then prepared into tabletes by tabletting.
The ganoderma and thunder god vine of said portions may be further added into above raw material herbs to prepare the medicament of the invention which can restore health and eliminate pathogens and enhance curative effect.
The medicament of the invention has the effect of eliminating heat and clearing fire, diminishing inflammation, antibiosis, cooling blood and closing sore, etc., which can be used to treat recurrent ulcer in mouth and Behcet's Syndrome.
In the medicament of the invention the root of Coptis chinesis is used as the sovereign component, which with cold nature and bitter flavour, enters heart, liver, stomach and large intestine meridian, and has the effect of clearing heat, drying dampness, draining fire, especially eliminating excessive heat in heart and stomach, removing toxin, and curing sore-toxin. The root of
Coptis chinesis
is chosen as the sovereign component, for it treats accumulated heat in heart and spleen and cures sore.
The
Corydalis bungeana,
the Isatis root and puccoon are used as the ministerial components in the invention.
Corydalis bungeana
with cold nature and acrid and bitter flavour enters heart and spleen meridian, and has the effect of clearing heat and removing toxin. Due to its discharging effect of bitterness, dissipating effect of acridity, and clearing heat of cold nature, it is used for treating stagnation of blood and heat, red-swelling, heat-pain, and swelling and pain of sore-toxin. Isatis root with cold nature and bitter flavor enters heart and stomach meridian and has the effect of clearing heat, removing toxin, cooling blood and nourishing throat, which is used for the treatment of fever, headache, swelling sore in throat, swollen and painful sore-toxin. Puccoon with cold nature and sweet flavor enters heart and liver meridian and has the effect of cooling blood, activating blood, removing toxin and releasing pain, which is used for the treatment of hot blood, accumulated toxin and swollen and painful sores. These three herbs with the effect of clearing heat, removing toxin and cooling blood combine together to assist the effect of sovereign component, the root of
Coptis chinesis
, on heat-clearing, toxin-resolving and sore-treating, as ministerial components.
In the medicament of the invention, flower of lonicera, bamboo leaf, snake gallbladder, root dried Rhemannia and the lily bulb are used as adjuvant components. Flower of lonicera with cold nature and sweet flavor enters lung, heart and stomach meridian and has the effect of clearing heat, removing toxin, dissipating wind and heat, releasing pain and dispersing swelling, which is an important component for treatment of swollen and painful sores. Bamboo leaf with cold nature and bland, acrid and sweet flavor enters heart, stomach and small intestine meridian and has the effect of clearing heat, eliminating vexation, engendering liquid
Bromberg & Sunstein LLP
Flood Michele
Lankford , Jr. Leon B.
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