Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-02-18
1994-02-22
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514866, A61K 3702, C07K 706
Patent
active
052887065
DESCRIPTION:
BRIEF SUMMARY
INDUSTRIAL APPLICABILITY
The present invention relates to a new medicament and a veterinary medicament. More particularly, the present invention relates to a medicament possessing hypoglycemic activity, insulitis blocking activity, anti-obese activity and anti-adiposis activity and being utilized for prevention and remedy of various types of diabetes, acute pancreatitis, chronic pancreatitis, corpulence, hyperlipidemia, diapetic neuropathy and atheromatous arteriosclerosis as well as a new medicament for prevention and remedy of gastritis, constipation, infected gastrointestinal canal, meteorismus, irritable colon syndrome, caries, hepatitis, diseases such as nephritis, and diseases of adrenal gland.
BACKGROUND ART
In Europe, America and Japan, the age of the population is now being older so that the number of patients suffering from adult diseases is increased. Diabetes is known as one of such adult diseases, which is classified into insulin dependent diabetes mellitus (referred to hereinafter as IDDM) and non-insulin dependent diabetes mellitus (referred to hereinafter as NIDDM).
It is known that IDDM chiefly attacks people of younger ages and that people of 18 years old are attacked by IDDM in Europe and America at a rate as high as 1/300-500 persons. The majority of diabetes patients are compelled to receive injection of insulin over their life span, thus raising many problems personally and socially.
Diabetes incurs various metabolic disordered based on the metabolic disorder of insulin and sugar and causes disorder in blood vessels and nervous system, thus being regarded as a terrible sickness attacking almost all organs in living body. Accordingly, an effective method for the remedy of diabetes is rapidly demanded.
At present, an insulin treatment or oral anti-diabetes drugs such as sulfonylurea preparations and biguanide preparations are used widely as a means for the remedy of diabetes. However, all of these preparations only serves to reduce the level of blood sugar allopathically but fail to become medicaments for completely curing diabetes.
In connection with the cause and factor of diabetes, there are a number of unsolved problems, but hereditary background and environmental factor are also regarded to be important. The infection of virus and some chemical substances are known as the environmental factor. A detailed contract mechanism of these is not yet known but autoimmunity mechanism to Langerhans islands is thought to be a cause of the attack.
Pancreatitis involving acute and chronic pancreatitis accompanying necrosis is a disease which may incur death if left without any treatment. In recent years, gabexate mesylate preparations are applied to this disease.
The present inventors have contemplated to develop a new type medicament which can be expected to be effective for complete remedy of diabetes and acute pancreatitis and for reducing these symptoms.
DISCLOSURE OF THE INVENTION
The present inventors have made extensive researches for finding such medicament in various peptides of natural origin which are of high safety.
As a result of the researches, it has been found for the first time that a nonapeptide known as the factor of thymic serum (FTS: Facteur thymique serique) and derivatives or salts thereof are effective to inhibit increase in the level of blood sugar of rats to which alloxan or streptozotosine has been administered. The present invention has been accomplished on the basis of the above finding and provides a medicament for prevention and remedy of various diseases including diabetes which contains the above nonapeptide or a derivative thereof as an effective ingredient.
One of the present inventors previously found that FTS was suitable as a therapeutic agent for multiple sclerosis, Guillain-Barre syndrome, inflammatory neuritis, polyneuritis and other various diseases accompanying immunodeficiency such as immunological demyelinating diseases, and provided such therapeutic agents (Japanese Laid-open Patent Appln. No. Sho. 58-52225). The fact that a nonapeptide known
REFERENCES:
patent: 4098777 (1978-07-01), Veber et al.
patent: 4229438 (1980-10-01), Fujino et al.
patent: 4301065 (1981-11-01), Bach et al.
patent: 4680276 (1987-07-01), Bach et al.
Anatomical Record, 109, p. 377, 1951.
Clinics in Immunology and Allergy, 3(1), p. 133, 1983.
Kolb et al., Diabetes Research, vol. 6, No. 1, pp. 21-27, 1987.
Fabris et al, Cellular Immunology, vol. 91, No. 2, pp. 325-335, 1985.
Abe Hayao
Awaya Akira
Ishizuka Yusaku
Kobayashi Hisashi
Yamanouchi Toshikazu
Lee Lester L.
Mitsui Toatsu Chemicals Incorporated
LandOfFree
Medicament for prevention and remedy of diseases of the pancreas does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Medicament for prevention and remedy of diseases of the pancreas, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Medicament for prevention and remedy of diseases of the pancreas will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-171231