Surgery – Liquid medicament atomizer or sprayer
Patent
1993-04-22
1995-09-05
Burr, Edgar S.
Surgery
Liquid medicament atomizer or sprayer
12820023, A61M 1100
Patent
active
054471508
DESCRIPTION:
BRIEF SUMMARY
This invention relates to a dispensing device, and more specifically, to a device suitable for dispensing discrete amounts of fluid.
In particular, the invention is concerned with a dispensing device of the type where the metered dose is administered in response to the inhalation of the patient.
Metered dose inhalers are well known in medicine for treatment, or alleviation of the effects of respiratory complaints, for example asthma. Breath-actuated devices are also known, and have been the subject of many patent applications.
GB 1288971; GB 1297993; GB 1335378; GB 1383761; GB 1392192; GB 1413285; W085/01880; GB 2204799; U.S. Pat. No. 4,803,978 and EP 0186280A describe inhalation-actuated dispensing devices for use with a pressurised aerosol dispensing container. The device includes a dispensing container and the container includes a valve capable of releasing a metered amount of the aerosol contents, when an internal spring operating the valve is compressed by a sufficient amount. The dispensing device often comprises a chamber having a mouthpiece, air inlets, actuating means for causing the actuation of the valve in the dispensing container, a latching means for releasably retaining said metering valve in a charged position, and an inhalation responsive means for releasing the latch, such that a metered amount of aerosol compound is discharged into the region of the mouthpiece. The overall objective is to give co-ordination of discharge of medicament from the aerosol container with inhalation of the patient, thus allowing a maximum dose of medicament to reach the bronchial passages of the lungs.
The latching means is often connected to a valve which moves from a latching position to a dispensing position in response to a partial vacuum developed upon inhalation.
EP-A-0045419 describes an inhalation device having biassing means which are alone of insufficient force to depress the container but which together are of sufficient force to do so.
EP-A-186280 describes a device which employs magnets to control the release of the aerosol container.
U.S. Pat. No. 3,605,738 describes devices in which the aerosol container communicates with the mouthpiece via a metering chamber. A metered quantity of the aerosol compound is discharged into the metering chamber and this is conveyed to the mouthpiece via an inhalation-actuated valve.
GB 1269554 describes a device wherein the aerosol container is moveable by a lever and cam system into a charged position held by a latch, a pressure differential acting to trip the latch and move the valve of the container to a discharge position.
It is the object of this invention to provide a metered dose inhaler, wherein the release of the medicament is actuated by the inhalation of the patient. It is a further object of the invention to provide an inhalation-actuated device which is more simple and compact than the prior art dispensers.
According to one aspect of the present invention there is provided a dispensing device for use with a drug delivery system comprising a means for releasing a measured dose of medicament from the system, the releasing means comprising a means for applying a preload capable of actuating the delivery means in the system, a means for applying a resisting pneumatic force capable of preventing actuation of the delivery means and a release device capable of freeing the resisting pneumatic force to allow the preload to actuate the delivery means and dispense the medicament.
The pneumatic resisting means may be provided by air which is either held at a positive pressure greater than atmospheric or a negative pressure below atmospheric prior to release. The release device will act to return the pressure to atmospheric or prior equilibrium, thus allowing the full force of the preload to act.
The device is particularly suited for use with pressurised inhalation aerosols having valves as the delivery means.
Although this device has been described in particular relation to a system using air, it will be realised that in a closed system any suitable gas could be us
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Burr Edgar S.
Lewis Aaron J.
Norton Healthcare Limited
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