Medicament containing an effector of the glutathione...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C549S039000

Reexamination Certificate

active

10478174

ABSTRACT:
The invention relates to a medicament containing an effector of the glutathione metabolism together with α-lipoic acid for treating diabetes mellitus. This medicament enables disturbances of the thiol-disulfide status or those that occur, for example, in diabetes mellitus to be treated simultaneously, separately or in a temporally graduated manner.

REFERENCES:
patent: 44 20 102 (1995-12-01), None
patent: 198 06 354 (1999-08-01), None
Gillissen et al., Respiratory Med. (1998), vol. 92, pp. 609-623.
Derick et al., Biochem. Biophy. Research Comm. (1995), vol. 207, No. 1, pp. 258-264.
Jablonka et al., Archivum Veterinarium Polonicum (1992), vol. 32 (1-2), p. 57-66.
Biewenga et al., Gen. Pharmac (1997), vol. 29, No. 3, p. 315-331.
Kahler, Kuklinski, et al.; Diabetes mellitus; Innere Medizin, pp. 223-232; May 1993.
Borcea, Nourooz-Zadeh, et al; Lipoic Acid Decreases Oxidative Stress Even in Diabetic Patients . . . ; Free Radical Biology & Medicine, vol. 22, Nos. 11/12, pp. 1495-1500; 1999.
Hofmann, Schiekofer, et al.; Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy . . . ; Diabetologia, pp. 222-232; Spring 1999.
Jablonka, Ledwozyw, et al.; The influence of Ambroxol on peroxidative processes . . . ; Archivum Veterinarium Polonicum 32; pp. 57-66; 1992.

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