Medicament and its production and use in the treatment of pain,

Details Medicament and its production and use in the treatment of pain, Medicament and its production and use in the treatment of pain,

1991-05-16

1993-04-27

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424436, 424456, 424465, 514570, A61K 914, A61K 948, A61K 3119

Patent

active

052060292

ABSTRACT:
The present invention provides a medicament for the treatment of painful and/or inflammatory diseases and/or of fever with flurbiprofen, wherein the previously separated enantiomers of flurbiprofen are worked up in a ratio of 99.5-0.5% to 0.5-99.5%, in combination with conventional pharmaceutical carriers and adjuvants, to give a medicament.

REFERENCES:
patent: 3784705 (1974-01-01), Adams et al.
patent: 4209638 (1980-06-01), Nicholson et al.
Caldwell et al., The Metabolic Chiral Inversion and Dispositional Enantio Selectivity of the 2-aryl Propionic Acids, 1988, Biochemical Pharmacology, vol. 37.
F. Jamali, Pharmacokinetics of Enantiomers of Chiral non-Steroidal anti-inflammatory Drugs, 1987, European Journal of Drug Metabolism . . . vol. 13.
Hutt et al., The Importance of Stereochemistry in the Chiral Pharmacokonetics of the 2 aryl propionic acids NSAIDS, 1984, Clinical Pharaco Kinetics, vol. 9.
Br. J. Clin. Pharmac. (1980), 10, 233S-235S. Gerald A. Higgs, Arachidonic Acid Metabolism, Pain and Hyperalgesia: . . . .
Nature New Biology vol. 231, Jun. 23, 1971, J. R. Vane, Inhibition of Prostaglandin Synthesis as a Mechanism of Action . . . .
Abstract No. A-4, Flurbiprofen. Flurbiprofen Dextrorotatroy Component (BTS 24332), and Placebo in Postepisiotomy Pain . . . .
Martindale, The Extra Pharmacopoeia, 29th Edition, 1989.

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