Medicament and its production and use in the treatment of pain,

Details Medicament and its production and use in the treatment of pain, Medicament and its production and use in the treatment of pain,

1991-05-16

1993-04-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424436, 424456, 424465, 514570, A61K 914, A61K 948, A61K 3119

Patent

active

052001989

ABSTRACT:
The present invention provides a medicament for the treatment of painful and/or inflammatory diseases and/or of fever with flurbiprofen, wherein the flurbiprofen is pure or preponderantly R(-)-flurbiprofen worked up in combination with conventional pharmaceutical carriers and adjuvants, to give a medicament.

REFERENCES:
patent: 3784705 (1974-01-01), Adams et al.
patent: 4209638 (1980-06-01), Nicholson et al.
Caldwell et al., The Metabolic Choral Inversion and Dispositioned Enantioselectivity of the 2-Aryl Propionic Acids, Biological Pharmacology, 1988.
Jamali, Pharmacokinetis of Enantiomers of Chiral NSAID's, European Journal of Drug Metabolism and Pharmacokinetics, vol. 13, 1988.
Hutt et al., The Importance of Stereochemistry in the Clinical Pharmacokinetics of the 2-Arylpropionic Acid NSAID's, Clinical Pharmacolokinetis vol. 9, 1984.
Martindale, The Extra Pharmacopoeia, 29th Edition, 1989.
Br. J. Clin. Pharmac. (1980), 10, 233S-235S. Gerald A. Higgs, Arachidonic Acid Metabolism, Pain and Hyperalgesia: . . . .
Nature New Biology vol. 231, Jun. 23, 1971, J. R. Vane, Inhibition of Prostaglandin Synthesis as a Mechanism of Action . . . .
Abstract No. A-4, Flurbiprofen, Flurbiprofen Dextrorotatroy Component (BTS 24332), and Placebo in Postepisiotomy Pain . . . .

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