Medicament against infertility which reduces phagocytosis of spe

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514626, A61K 31445, A61K 3116

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active

059771437

ABSTRACT:
The present investigation relates to the use of a local anesthetic for the manufacture of a medicament for use against infertility or for increasing fertility. It also relates to a pharmaceutical composition comprising a pharmaceutically effective dose of a local anesthetic together with a pharmaceutically acceptable excipient. It also relates to a process for increasing fertility in a woman with said pharmaceutical composition.

REFERENCES:
Medline Abstract, AN:95200153 (1995) Doherty, M.M. et al.
Gennaro, A.R. et al., Remington's Pharmaceutical Sciences (18.sup.th Ed.) (1990), Mack Pub. Co., Easton, PA., pp. 1048-1053, 805-806 and 820-821.
Publication in Favour (1) and Against (2) the Use of Lignocaine During Fertilisation; manuscript by Greta Edelstam, M.D., Ph.D.; May 15, 1997; 7 pages.
The Effect of Lignocaine on Sperm Phagocytosis in the Peritoneal Fluid From Women with and without Endometriosis; Greta A.B. Edelstam, M.D., Ph.D.; Eva Andersson; Arne R.ang.destad, M.D., Ph.D.; Folke Flam, M.D. Assoc. Prof; Claes Gottlieb, M.D. Assoc. Prof.; (1998),Hum. Reprod., 13(5), pp. 1353-1356.
Sperm phagocytosis by human peritoneal macrophages: A possible cause of infertility in endometriosis, Joseph J. Muscato, M.D.; A.F. Haney, M.D.; and J. Brice Weinberg, M.D., pp. 503 through 510, American Journal of Obstetric Gynecology; Nov. 1, 1982.
Hyaluronan and Myeloperoxidase in Human Peritoneal Fluid During Genital Inflammation, Greta A.B. Edelstam, Orjan Lundkvist, Per Venge, and Torvard C. Laurent; Inflammation, vol. 18, No. 1, 1994; pp. 13 through 21.
Role of Periotoneal Inflammation in Endometriosis-associated Infertility, Jouko Halme; Annals New York Academy of Sciences, pp. 266 through 275; (1991).
Pathophysiology of mild endometriosis: review of literature, Tahir A. Mahmood and Allan Templeton; Human Reproduction, vol. 5, No. 7, 1990, pp. 765-782.
Sperm survival studies in peritoneal fluid from infertile women with endometriosis and unexplained infertility by Makarand K. Oak, Eric N. Chantler, Catherine A. Vaughan Williams and Max Elstein; Clinical Reproduction and Fertility(1985) 3, pp. 297 through 303; (1985).
Peritoneal Fluid Cell Populations in Infertility Patients, A.F. Haney, M.D., Joseph J. Muscato, M.D., and J. Brice Weinberg, M.D.; Fertility and Sterility, vol. 35, No. 6, Jun. 1981, pp. 696, 697, and 698.
Semen preparation with the Sperm Select system versus a washing technique, Elizabeth R. Zimmerman, M.D., Kathryn R. Robertson, B.S., Helen Kim, B.S., Erma Z. Drobnis, Ph.D., and Steven T. Nakajima, M.D.; Fertility and Sterility, vol. 61, No. 2, Feb. 1994; pp. 269 through 275.
An ovum capture inhibitor (OCI) in endometriosis peritoneal fluid: an OCI-related membrane responsible for fimbrial failure of ovum capture, Hiroshi Suginami, J.D. and Kohji Yano, M.D., The American Fertility Society , vol. 50, No. 4, Oct. 1988, pp. 648 through 653.
Peritoneal macrophages and infertility: the association between cell number and pelvic pathology, David L. Olive, M.D., J. Brice Weinberg, M.D., and Arthur F. Haney, M.D.; The American Fertility Society, vol. 44, No. 6, Dec. 1985; pp. 772 through 777.
Preparation of pure hepatocytes and reticuloendothelial cells in high yield from a single rat liver by means of Percoll centrifugation and selective adherence, B.ang.rd Smedsrod and H.ang.kan Pertoft; J. Leukocyte Biol., (1985), 38/2, pp. 213-230.
Peritoneal Macrophages From Patients With Endometriosis Release Growth Factor Activity in Vitro, J. Halme, C. White, S. Kauma, J. Estes, and S. Haskill; Journal of Clinical Endocrinology and Metabolism, vol. 66, No. 5, 1988, pp. 1044 through 1049.
The Effects of Lignocaine on Human Sperm Motility, Stephen John Bennett, Virginia Bolton, and John Parsons; Journal of Assisted Reproduction and Genetics vol. 9, No. 3, 1992; pp. 271 through 273.
Follicular fluid Lidocaine levels during transvaginal oocyte retrieval, Dwight D. Bailey-Pridham, M.D., Eli Reshef, M.D.; Kenneth Drury, Ph.D.; Christine L. Cook, M.D.; Harrell E. Hurst, Ph.D.; and Marvin A. Yussman, M.D.; Fertility and Sterility, vol. 53, No. 1, Jan. 1990; pp. 171, 172, 173.
Effect of peritoneal fluid on sperm motility and velocity distribution using objective measurements, Gianni Soldati, M.Sc.; Ana Piffaretti-Yanez, M.Sc.; Aldo Campana, M.D.; Maurizio Marchini, M.D.; Massimo Luerti, M.D.; Marco Balerna, Ph.D.; Fertility and Sterility, vol. 52, No. 1, Jul. 1989; pp. 113 through 119.
Toxicological Assessment of Lidocaine in the Pregnant Rat, L. J. Ramazzotto, F. A. Curro, J.A. Paterson, P. Tanner, and M. Coleman; J. Dent Res, vol. 64, No. 10; Oct. 1985; pp. 1214 through 1217.

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