Medical uses of scuPA/suPAR complex

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor

Reexamination Certificate

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C435S004000, C435S007100, C435S007210, C435S007910, C435S007920, C436S086000, C436S536000, C436S512000, C436S513000, C530S350000, C530S380000, C530S300000, C530S385000, C530S386000, C530S387100, C514S001000, C514S002600, C514S014800

Reexamination Certificate

active

06911316

ABSTRACT:
Methods of using a complex (scuPA/suPAR) which has thrombolytic activity under physiological conditions and in the presence of IgG, or of at least one IgG-derived peptide, which complex comprises a single chain urokinase type plasminogen activator (scuPA) and a soluble urokinase plasminogen activator receptor (suPAR), for the treatment and/or prevention of thromboembolic disorders associated with the formation of fibrin clots are disclosed.

REFERENCES:
patent: 5455044 (1995-10-01), Kim et al.
patent: 5558852 (1996-09-01), Bigner et al.
Harlow and Lane. Antibodies, A Laboratory Manual, Chapter 59:96-99, 1988.
Lindahl, T.L. et al., “The mechanism of the reaction between human plasminogen-activator inhibitor 1 and tissue plasminogen activator,”Biochem. J. 265(1):109-113 (1990).
Ploug, M. et al., “Ligand Interaction between Urokinase-Type Plasminogen Activator and Its Receptor Probed with 8-Anilino-1-naphthalenesulfonate. Evidence for a Hydrophobic Binding Site Exposed Only on the Intact Receptor,”Biochemistry, 33:8991-8997 (1994).
Pannell; R. et al., “Activation of Plasminogen by Single-Chain Urokinase or by Two-Chain Urokinase—A Demonstration That Single-Chain Urokinase Has a Low Catalytic Activity (Pro-Urokinase),”Blood, 69(1):22-26 (1987).
Collen, D., “On the Regulation and Control of Fibrinolysis,”Thrombosis and Haemostasis, 43(2):77-89 (1980).
Lijnen, H.R. et al., “The Mechanism of Plasminogen Activation and Fibrin Dissolution by Single Chain Urokinase-Type Plasminogen Activator in a Plasma Milieu In Vitro,”Blood, 73(7):1864-1872 (1989).
Wang, J. et al., “Plasminogen activation by pro-urokinase in complex with its receptor Dependence on a tripeptide (Spectrozyme plasmin),”Eur. J. Biochem. 247(1):256-261 (1997).
Behrendt, N. et al., “Reply to comment on ‘Effect of purified, soluble urokinase receptor on the plasminogen-prourokinase activation system’ (A.A-R. Higazi),”FEBS Letters 402:293-294 (1997).
Deutsch, D.G. et al., “Plasminogen: Purification from Human Plasma by Affinity Chromatography,”Science, 170(3962):1095-1096 (1970).
Kasai, S. et al., “Primary Structure of Single-chain Pro-urokinase,”J. Biol. Chem., 260(22):12382-12389 (1985).
Ellis, V. et al., “Inhibition of Receptor-bound Urokinase by Plasminogen-activator Inhibitors,”J. Biol. Chem., 265(17):9904-9908 (1990).
Ellis, V. et al., “Plasminogen Activation by Receptor-bound Urokinase,”J. Biol. Chem., 266(19):12752-12758 (1991).
Schwartz, B.S., “Differential Inhibition of Soluble and Cell Surface Receptor-bound Single chain Urokinase by Plasminogen Activator Inhibitor Type 2,”J. Biol. Chem., 269(11):8319-8323 (1994).
Higazi, A.A. et al., “Identification of an Inhibitor of Tissue-type Plasminogen Activator-mediated Fibrinolysis in Human Neutrophils,”J. Biol. Chem. 270(16):9472-9477 (1995).
Del Villar, K. et al., “Amino Acid Substitutions That Convert the Protein Substrate Specificity of Farnesyltransferase to That of Geranylgeranyltransferase Type I,”J. Biol. Chem., 272(1):680-687 (1997).
Zhang, L. et al., “Regulation of Single Chain Urokinase Binding, Internalization, and Degradation by a Plasminogen Activator Inhibitor 1-Derived Peptide,”J. Biol. Chem. 272(43):27053-27057 (1997).
Behrendt, N. et al., “Domain Interplay in the Urokinase Receptor,”J. Biol. Chem., 271(37):22885-22894 (1996).
Ellis, V., “Functional Analysis of the Cellular Receptor for Urokinase in Plasminogen Activation,”J. Biol. Chem., 271(25):14779-14784 (1996). JBC OnlineBio. Mol.pp. 1-13.
Higazi, A.A. et al., “Regulation of fibrinolysis by non-esterified fatty acids,”Biochem J., 300:251-255 (1994).
Higazi, A.A. et al., “Regulation of Single Chain Urokinase by Small Peptides,”Thromb. Res. 84(4):243-252 (1996).
Higazi, A.A. et al., “Enhancement of the Enzymatic Activity of Single-chain Urokinase Plasminogen Activator by Soluble Urokinase Receptor,”J. Biol. Chem. 270(29):17375-17380 (1995).
Higazi, A.A. et al., “Unesterified Long Chain Fatty Acids Inhibit the Binding of Single Chain Urokinase to the Urokinase Receptor,”Biochemistry, 35(21):6884-6890 (1996).
Higazi, A.A. et al., “Interaction of Single-Chain Urokinase With Its Receptor Induces the Appearance and Disappearance of Binding Epitopes Within the Resultant Complex for Other Cell Surface Proteins.”Blood, 88(2):542-551 (1996).
Higazi, A.A. et al., “Single Chain Urokinase-Type Plasminogen Activator Bound To Its Receptor Is Relatively Resistant To Plasminogen Activator Inhibitor Type 1,”Blood, 87(9):3545-3549 (1996).
Higazi, A.A. et al., “Lysis of Plasma Clots by Urokinase-Soluble Urokinase Receptor Complexes,”Blood, 92(6):2075-2083(1998).
Higazi, A.A. et al., “Soluble Human Urokinase Receptor Is Composed of Two Active Units,”J. Biol. Chem., 272(8):5348-5353 (1997).
Higazi, A.A., “Commentary on: ‘Effect of purified soluble urokinase receptor on the plasminogen prourokinase activation system’ by N. Behrendt and K. Dano,FEBS Letters, 393(1996) 31-36”,FEBS Letters 402:291-292 (1997).
Behrendt, N., et al., “The Structure and Function of the Urokinase Receptor, a Membrane Protein Governing Plasminogen Activation on the Cell Surface,”Biol. Chem. Hoppe-Seyler 376:269-279 (1995).

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