Medical uses of allosteric hemoglobin modifier compounds in pati

Details Medical uses of allosteric hemoglobin modifier compounds in pati Medical uses of allosteric hemoglobin modifier compounds in pati

1995-06-07

1997-10-14

Nazario-Gonzalez, Porfirio

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514486, 514512, 514513, 514533, 514534, 514538, 514833, 548403, 548416, 548473, 548478, 562425, 562452, 562455, A61K 3140, C07D20948, C07D22900

Patent

active

056773307

ABSTRACT:
A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The effect has particular application in a wide variety of treatments including hypoxia, hypothermia, ischemia, stroke, ARDS, COPD, surgical blood loss, acute nonvolemic hemodilutions, wounds, diabetic ulcers, chronic leg ulcers, pressure sores, tissue transplants, and sepsis. The compounds are capable of acting on hemoglobin in whole blood.

REFERENCES:
patent: 5049695 (1991-09-01), Abraham et al.
patent: 5122539 (1992-06-01), Abraham et al.
patent: 5248785 (1993-09-01), Abraham et al.
patent: 5290803 (1994-03-01), Abraham et al.

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