Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-06-30
1996-07-23
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514213, 514214, 514221, 514322, 514317, 514559, 514568, 514648, 514650, 514654, 514561, 514872, A61K 3144, A61K 3120, A61K 3155, A61K 31135
Patent
active
055389821
ABSTRACT:
The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharmaceutical compositions containing them and their medical use. ##STR1## wherein R represents the ring A ##STR2## or 2-pyridinyl or 2-pyridinyl-N-oxide; R.sup.1 is selected from halogen atoms and C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, and S(O).sub.n C.sub.1-4 alkyl groups;
REFERENCES:
patent: 5102667 (1992-04-01), Dubruoequ et al.
Newton et al., J. Comp. Neurol., 234, 87-104 1985.
Lesley, Neurochem. Int., 7, 191-211. 1985.
Andrews et al., TIPS, 9, 334-341. Sep. 1988.
Carpenter et al., Cell. and Mol. Neurobiol., 3, 113,126. 1983.
Carpenter et al., Fed. Prod. Am. Soc. Exp. Biol., 43, 2952-2954. Dec. 1984.
Saffroy et al., Peptides, 9, 227-241. 1988.
Bunce Keith T.
Hagan Russell M.
Criares Theodore J.
Glaxo Group Limited
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