Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1990-11-14
1993-08-17
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
1286531, A61K 4900
Patent
active
052366936
ABSTRACT:
A medical ultrasound contrast agent and method of using the same wherein the contrast agent comprises a pharmaceutically acceptable carrier in combination with a substantially solid, radioactively opaque, biodegradable particle. The particle is of a size allowing it to be passed through the lungs to the left side of the heart where it may be visualized by conventional medical ultrasound.
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Smith et al. "Superior Intensity and Reproducibility of SHU-454 . . . " J. Am. Coll. Cardiol., 1984 (Apr.), vol. 3(4), pp. 992-998; abstract in Medline AN 84163099.
Smith et al., "Left Heart Opacification . . . " J. Am. Coll. Cardiol., 1989 (Jun.) vol. 13(7), pp. 1622-1628; abstract in Medline AN 89256357.
Shapiro, J. R. et al. JACC 13:1629-30 (1989), No. 7.
Lindberg, B. et al., Microspheres and Drug Therapy, Pharmaceutical, Immunological and Medical Aspects, Chapter 1:153-188 (1984), Elsevier Sc. Pub. B.V.
Tuma, R. F., Microspheres and Drug Therapy, Pharmaceutical, Immunological and Medical Aspects, Chapter 2:189-203 (1984) Elsevier Sc. Pub. B.V.
Brigham and Women's Hospital
Pak John D.
Raymond Richard L.
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