Medical prosthetic devices having improved biocompatibility

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Bone

Reexamination Certificate

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Details

C424S423000, C623S023570, C623S023600, C623S023760, C623S923000

Reexamination Certificate

active

07410502

ABSTRACT:
The invention relates to a medical prosthetic device having a metal material, such as titanium or an alloy thereof, where the surface parts of the metal material are coated with a layer of a corresponding hydroxide material, such as titanium hydroxide. Preferably, the hydroxide layer includes one or more biomolecule substances associated therewith. The invention also relates to an electrolytic process for the preparation of a medical prosthetic device.

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patent: 5211663 (1993-05-01), Kovacs et al.
patent: 5609633 (1997-03-01), Kokubo
patent: 5612049 (1997-03-01), Li et al.
patent: 6190412 (2001-02-01), Lee et al.
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patent: WO-9727821 (1997-08-01), None
patent: WO-98/35920 (1998-08-01), None
patent: WO 00/38753 (2000-07-01), None
patent: WO 00/72777 (2000-12-01), None
patent: WO 02/45764 (2002-06-01), None
Tengvall, P et al. “Physico-chemical considerations of titanium as a biomaterial.”Clinical Materials9:115-134 (1992).
Ellingsen et al., Materials in Clinical Applications, 1995, pp. 543-550.
Arsov et al., J. Electrochem. Soc., vol. 138, No. 10, Oct. 1991, pp. 2964-2970.
S. K. Yen et al.,Biomaterials(2001) 22(2), 125-133.

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