Medical prosthetic devices and implants having improved...

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis

Reexamination Certificate

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C623S001100, C623S002100, C623S016110, C623S023530, C623S023570, C623S023600, C606S060000, C606S067000, C606S064000, C606S076000

Reexamination Certificate

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10010140

ABSTRACT:
Disclosed are medical prosthetic devices or medical implants which exhibit improved biocompatitibly. The devices or implants include a metal material, e.g. titanium, in which the metal surface parts are coated with a corresponding hydride material that contains one or more biomolecule substance. This biomolecule substance may contain one or more biologically active molecules, e.g. bio-adhesives, biopolymers, blood proteins, enzymes, extra cellular matrix proteins, extra cellular matrix biomolecules, growth factors and hormones, peptide hormones, deoxyribonucleic acids, ribonucleic acids, receptors, enzyme inhibitors, drugs, biologically active anions and cations, vitamins, adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine triphosphate (ATP), marker biomuolecules, amino acids, fatty acids, nucleotides (RNA and DNA bases), or sugars.

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Conforto, E. et al., “Crystallographic properties and mechanical behaviour of titanium hydride layers grown on titanium implants,”Philosophical Magazine, vol. 84(7):631-645 (Mar. 2004).

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