Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1996-11-13
1998-07-28
Phelan, D. Gabrielle
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424449, A61F 1302
Patent
active
057859850
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/EP95/01723, filed May 5, 1995.
BACKGROUND OF THE INVENTION
The present invention relates to medical pressure-sensitive adhesive masses having a high moisture vapor transmission (MVT) of at least 10,000 g/m.sup.2 /24.h (measured according to the inverted cup method at 40.degree. C. and 80% .DELTA. r.h. using a pressure-sensitive adhesive film having a weight of 30 g/m.sup.2) and an excellent adhesion to dry and freely perspiring skin. The present invention further relates to their production and use.
Medical pressure-sensitive adhesive masses having a high MVT and a high adhesive force on skin that is moist owing to heavy perspiration have been known for some time. However, these pressure-sensitive adhesive masses have some disadvantages limiting their practical use to a great extent.
The state of the art in this field may be described as follows:
U.S. Pat. No. 5,057,179 describes a polar dispersion based on polyvinyl acetate, which has a good adhesion to moist substrates.
JP-A 31 62473 describes a pressure-sensitive adhesive mass with adhesion to moist surfaces. This pressure-sensitive adhesive mass consists of an acrylate copolymer built-up of alkyl acrylate, alkylene alkoxyacrylate, and vinylcarboxylic acid, and an ethylene vinyl acetate copolymer.
JP-A 30068672 includes adhesive tapes for medical patches adhering to moist or dry skin. These products comprise silicone pressure-sensitive adhesive masses and water-soluble carboxyvinyl polymers, cellulose derivatives or starch derivatives.
JP-A 62091577 describes pressure-sensitive adhesive masses with a marked adhesion to dry and moist substrates, the adhesion to moist substrates being achieved by introduction of water absorbing agents based on cross-linked polyacrylate salts.
JP-A 61290956 describes resins for medical pressure-sensitive adhesive masses composed of acrylamide derivatives, (meth)acrylates, and glycol acrylic-acid esters.
WO 84013837 describes pressure-sensitive adhesive masses especially suitable for moist skin; these are based on copolymers of hydrophobic acrylates, hydrophobic vinyl polyethers, and polar monomers. (Meth)acrylic acid, itaconic acid, (meth)acrylamide, or n-vinyl pyrrolidone are used as a polar monomer.
GB-A 2070631 describes copolymers of butyl acrylate, ethylhexyl acrylate, and acrylic acid, for the use in medical products. In addition of cohesive properties, these copolymers have an adhesion to dry and moist skin and a vapor permeability of more than 300 g/m.sup.2 /24.h.
The prior art includes pressure-sensitive adhesive masses of differing compositions; they adhere to dry and moist skin but their adhesive power in case of heavy perspiration is reduced to such an extent that they cannot be used for patches.
The physiological acceptability of the employed raw materials has been of major importance in many pressure-sensitive adhesive masses classified as being suitable for medical purposes; but the MVT in adhesive medical products, also called breathability, has been left out of consideration. However, this is important for both protection of the skin from maceration, which results from moisture accumulation under the adhesive mass, and permanent adhesion to the skin, which is also impaired by moisture accumulation.
There is only scanty information about the MVT-values of prior art pressure-sensitive adhesive masses. From their chemical composition it can be concluded that they are insufficient for the application in case of intense perspiration. For example, the value of 300 g/m.sup.2 /24 h given as "lower limit" for the MVT in GB-A 2070631, is absolutely insufficient even in case of minor perspiration.
Test experience has shown that the MVT-values achievable with known pressure-sensitive adhesive masses are in the range of 1,000 to 8,000 g/m.sup.2 /24.h in case of pressure-sensitive adhesive layers having a weight per unit area of about 30 g/m.sup.2 ; this value is sufficient in some cases, however, is considered in need of improvement. Owing to their chemical composition, the known med
REFERENCES:
patent: 4721748 (1988-01-01), Iovine
patent: 5057179 (1991-10-01), Dulaney et al.
patent: 5346957 (1994-09-01), Tsuji
Czech Zbigniew
Seeger Kurt
Lohmann GmbH & Co. KG
Phelan D. Gabrielle
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