Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Patent
1999-03-29
2000-12-19
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
424646, 424655, 424682, 424688, 424691, A01N 5916, A01N 5906
Patent
active
061624691
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a magnetic medical powder. More particularly, this invention relates to a magnetic medical powder which is used as a drug carrier for drug delivery, an immunolatex, immunobeads, a medium for hyperthermia, etc.
BACKGROUND ART
A medical powder which comprises a polymeric microsphere obtained by a polymerization method, such as emulsion polymerization, soap-free emulsion polymerization, and having thereon an immobilized antigen or antibody, and which is used for diagnosis where its cohesiveness with an antigen or antibody as the substance to be detected is examined is conventionally known as an immunolatex. A technique of using a labeled antibody as the immobilized antibody in an immunolatex is used for heightening detectability in diagnosis. Also, a technique in which a drug is supported on an immnunolatex together with an antibody and this immunolatex is used for delivering the drug to, e.g., cancer cells having an antigen responsive to the supported antibody, is used.
Beads are more frequently used as drug carriers for drug delivery than latexes because they have the higher ability to support drugs. The term "beads" means polymeric microspheres having larger particle diameters than the latexes. Latexes have particle diameters in the range of about 100 .ANG. to about submicron sizes (1 .mu.m or less), while beads have particle diameters in the range of submicron sizes to several millimeters. The beads comprising a polymeric compound and having thereon an immobilized antigen or antibody are generally called immunobeads.
Beads comprising a polymeric compound which contain a drug embedded therein and have thereon an immobilized antibody are used for delivering the drug to a diseased part where a responsive antigen is present. Namely, these are a kind of drug delivery beads.
Although biodegradable natural polymeric compounds, i.e., gelatin, starch, fibrinogen, and the like, have been used as preferred bead materials for such drug delivery beads, they have drawbacks, for example, that particle diameter control is difficult, beads of constant quality are difficult to obtain, and storage is difficult. Consequently, use of synthetic or semisynthetic polymeric compounds is progressing.
The immobilization of an antigen or antibody on the latex particles or beads is accomplished, for example, by bonding the protein (constituent substance of the antigen or antibody) with a condensing agent, e.g., cyanogen bromide or carbodiimide, to a reactive group, e.g., a hydroxyl group, an amino group, or a carboxyl group, present on the main chain of the polymeric compound constituting the latex particles or beads or to such a reactive group incorporated as a side chain into the constituent polymeric compound through substitution.
Another known example of the fields where the immunobeads are utilized is the field of cell separation. An example of immunobead utilization in the field of cell separation is in therapy or diagnosis. In this application, magnetic immunobeads (hereinafter referred to also as "magnetosensitive immunobeads") are prepared by fixing a ferromagnetic substance to polymeric beads, for example, by incorporating an iron powder or another ferromagnetic material powder into the beads or embedding aggregates of ferromagnetic material powder particles in the beads and further immobilizing an antibody to the surface of the beads. The magnetosensitive immunobeads are introduced into the blood to allow the immunobeads to react with a responsive antigen (pathogenic antigen) present in the blood to thereby immobilize the antigen to the immunobeads. The magnetosensitive immunobeads are then collected with a magnet to thereby remove the antigen from the blood. The magnetosensitive immunobeads thus used for removing a pathogenic antigen from the blood are used also for removing tumor cells from bone marrow.
Still another use of magnetosensitive beads is in drug delivery. Specifically, magnetosensitive beads are used as a therapeutic powder in a drug delivery system in whic
REFERENCES:
patent: 5034145 (1991-07-01), Leising et al.
Atarashi Takafumi
Nakatsuka Katsuto
Dees Jos,e G.
Katsuta Nakatsuka
Nittetsu Mining Co., Ltd.
Pryor Alton
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