Medical material containing covalently bound heparin and process

Details Medical material containing covalently bound heparin and process Medical material containing covalently bound heparin and process

1990-09-26

1992-11-24

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424 7818, 523112, 525 542, 525 5421, 525 5423, 428288, 4283117, 428375, 428378, 428414, 428420, 428500, 428507, 428508, 428515, 428516, 428517, 428518, 210646, 210654, 210655, 21050024, 604 93, 623 1, A61K 31725, A61L 3300, B01D 7182, D06M 1503

Patent

active

051659190

DESCRIPTION:

BRIEF SUMMARY
TECHNICAL FIELD

This invention relates to a medical material, particularly a medical material having high antithrombotic property, as well as an intermediate therefor and processes for producing said medical material and intermediate.


BACKGROUND ART

Many methods have heretofore been proposed for imparting biocompatibility to medical materials.
Regenerated cellulosic materials are used advantageously as medical polymer materials, and it is well known to obtain anticoagulant medical polymer materials by fixing heparin to regenerated cellulose or derivatives thereof.
However, this method of fixing heparin directly to the substrate cellulose has only limited practical feasibility on account of problems such as insufficient heparin fixation.
Many processes have therefore, been proposed for producing medical polymeric materials to solve these problems. An exemplary process consists of reacting a heparin derivative with a polymerizable vinyl monomer and regenerated cellulose or a derivative thereof in an aqueous solvent in the presence of a polymerization initiator to thereby impart anticoagulation to the regenerated cellulose (see, for example, Unexamined Published Japanese Patent Application No. 162702/1982).


DISCLOSURE OF INVENTION

However, none of the methods discovered to date satisfy the requirement for increased throughput of treatments which is a particularly important factor for the biocompatibility to be imparted to medical materials.
For instance, one possible method consists of introducing functional groups at the surface of a material to be treated. However, aligning them on the surface is not practically feasible because of the difficulty involved in the molding technique employed.
Another possible method consists of coating after molding but no coating materials that are capable of solving the problem of delamination have yet been developed.
A coating material could be used as a binder but this method has a problem to be solved in association with the alignability of functional groups.
There has also been proposed a method that increases the throughput of treatments by making use of functional groups in a molded part. The major problem with this method is that the molded part is adversely affected by severe reaction conditions for introducing the functional groups to a polymeric material forming the molded part.
The present invention been accomplished with the aforementioned problems taken into account and its object is to provide a medical material having particularly high antithrombotic property, as well as an intermediate therefor and processes for producing said medical material and intermediate by increasing the amount of functional groups on a high-molecular weight compound.
In order to attain this object, the present invention provides a high-molecular weight (polymer) material comprising a high-molecular weight (first polymer) compound having functional groups capable of binding with epoxy groups and a (second) polymer having a number of epoxy groups, said functional groups being bound to some of said epoxy groups, with the other epoxy groups remaining unreacted.
In accordance with the present invention, there is also provided a high-molecular weight (polymer) material comprising a high-molecular weight (first polymer) compound having functional groups capable of binding with epoxy groups, a compound having at least two amino groups and a (second) polymer having a number of epoxy groups, said functional groups and some of said amino groups being bound to said epoxy groups, with the other amino groups remaining unreacted.
Preferably, the above-described (second) polymer having epoxy groups has a vinyl monomer as an essential component and has at least three epoxy groups per unit chain length.
According to the present invention, there is further provided a medical material comprising a high-molecular weight (polymer) material and a heparin derivative, said high-molecular weight (polymer) material comprising a high-molecular weight (first polymer) compound having functional groups capab

REFERENCES:
patent: 3917894 (1975-11-01), Coleman
patent: 4248736 (1981-02-01), Fuchigami et al.
patent: 4859758 (1989-08-01), Shalati et al.
patent: 4863907 (1989-09-01), Sakurai et al.

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