Medical devices composed of low ceiling temperature polymers

Details Medical devices composed of low ceiling temperature polymers Medical devices composed of low ceiling temperature polymers

1994-11-16

1996-10-08

Green, Randall L.

Surgery

Controlled release therapeutic device or system

604265, 424428, A61K 922

Patent

active

055626530

ABSTRACT:
The present invention provides shaped medical devices adapted for implant and subsequent in-vivo disintegration within a human or animal body. In one embodiment, the medical device is fabricated from a matrix polymer component, e.g., a lactam, which has a ceiling temperature (Tc) within the range of from about 40.degree. C. to about 76.degree. C. Decomposition of this device is accomplished by heating the device in-vivo to a temperature at or above the ceiling temperature of the matrix polymer component. In another embodiment, the medical device is fabricated from an end-capped polyoxyalkylene matrix polymer component characterized by a depolymerization temperature of at least about 40.degree. C. and a ceiling temperature of 76.degree. C. or less after removal of the end-cap group. In a third embodiment of the invention the medical device comprises a matrix polymer which is insoluble or only slightly soluble in normal body fluids and which exhibits a Tc below 40.degree. C. This device is stored and handled at T<Tc such that depolymerization and disintegration of the device does not begin until the device is implanted.

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