Medical device for pulsatile transdermal delivery of biologicall

Details Medical device for pulsatile transdermal delivery of biologicall Medical device for pulsatile transdermal delivery of biologicall

1985-10-30

1987-10-06

Rosenbaum, C. Fred

Surgery

Controlled release therapeutic device or system

Osmotic or diffusion pumped device or system

424449, A61K 900

Patent

active

046980628

ABSTRACT:
A medical device and method for the pulsatile administration of a drug through intact skin at a first steady state flux during a first delivery period and a second steady state flux during a second delivery period, said first flux being substantially higher than said second flux; said first and second delivery periods comprising a substantial portion of a predetermined administration period. The device comprises a reservoir of said drug containing an amount of drug sufficient to administer drug at said first and second steady state fluxes during administration period; a reservoir of a skin permeation enhancer for said drug; said reservoir containing an amount of said permeation enhancer sufficient to permit administration of said drug at said first flux only through said first delivery period; and means for maintaining said device on the skin in drug and permeation enhancer transferring relationship thereto a preferred embodiment delivering nitroglycerin and employing ethanol as a permeation enhancer. The device contains means for controlling the maximum delivery rate of one of said drug or enhancer. A preferred embodiment provides for the pulsatile delivery of nitroglycerin.

REFERENCES:
patent: 3625214 (1971-12-01), Higuchi
patent: 3797494 (1974-03-01), Zaffaroni
patent: 4031894 (1977-06-01), Urquhart et al.
patent: 4291015 (1981-09-01), Keith et al.
patent: 4336243 (1982-06-01), Sanvordeker et al.
patent: 4379454 (1983-04-01), Campbell et al.
patent: 4486193 (1984-12-01), Shaw et al.
patent: 4559054 (1985-12-01), Bruck

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