Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2011-04-05
2011-04-05
Azpuru, Carlos A (Department: 1617)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
Reexamination Certificate
active
07919110
ABSTRACT:
According to one aspect, implantable or insertable medical devices are provided, which contain polymeric release regions that release one or more therapeutic agents. The polymeric release regions, in turn, contain the following: (i) a first bonding polymer having a first polymer block and a first bonding group and (ii) a second bonding polymer having a second polymer block and a second bonding group. A therapeutic agent is disposed beneath or within the polymeric release region. The first and second polymer blocks can be the same as or different from one another, as can the first and second bonding groups. The first and second bonding groups are bound to one another via non-covalent bonding, for example, via electrostatic interaction, coordinative bonds, π-π stacking, or hydrogen bonding. According to another aspect, implantable or insertable medical devices are provided, which have a polymeric region that comprises (a) a first polymer having a first polymer block and a first bonding group and (b) a therapeutic agent having a bonding group that bonds to said first bonding group via non-covalent bonding at ambient temperature.
REFERENCES:
patent: 5840387 (1998-11-01), Berlowitz-Tarrant et al.
patent: 6071981 (2000-06-01), Johnson et al.
patent: 6545097 (2003-04-01), Pinchuk et al.
patent: 2004/0023155 (2004-02-01), Hayakawa
patent: 2004/0087755 (2004-05-01), Eling et al.
patent: 2004/0175406 (2004-09-01), Schwarz
Ranade, Shrirang V. et al., “Physical Characterization of Controlled Release of Paclitaxel fromt he TAXUS™ Express2™Drug-Eluting Stent”,Journal of Biomedical Materials Research, vol. 71A (2004): 625-634.
Ranade, Shrirang V. et al., “Styrenic Block Copolymers for Biomaterials and Drug Delivery Applications”,Acta Biomaterialia, vol. 1 (2005), pp. 137-144.
Binder Wolfgang H. et al., “Supramolecular Poly(ether ketone)-Polyisobutylene Pseudo-Block Copolymers”,Journal of Polymer Science: Part A: Polymer Chemistry, 2004, vol. 42, pp. 162-172.
Brunsveld, Luc et al., “Supramolecular Polymers,” MRS Bulletin, Apr. 2000, pp. 49-53.
Bosman, Anton W., et al., “Supramolecular polymers at work,” MaterialsToday, Apr. 2004, pp. 34-39.
Sherrington, David C., et al., “Self-assembly in synthetic macromolecular systems via multiple hydrogen bonding instructions,” Chem. Soc. Rev. 2001, vol. 30, pp. 83-93.
Pyun, Jeffrey et al., “Synthesis of Nanocomposite Organic/Inorganic Hybrid Materials using Controlled/“Living” Radical Polymerization,” Chem. Mater. 2001, vol. 13, 3436-3448.
Binder, Wolfgang H., et al., “Synthesis and Analysis of Telechelic Polyisobutylenes for Hydrogen-Bonded Supramolecular Pseudo-Block Copolymers,” Macromolecules, American Chemical Society, Jul. 2, 2003, revised Dec. 18, 2003, pp. A-K.
Azpuru Carlos A
Bonham David B.
Boston Scientific Scimed Inc.
Mayer & Williams PC
Park Keum J.
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