Radiant energy – Ionic separation or analysis – Methods
Reexamination Certificate
2007-08-07
2007-08-07
Nguyen, Kiet T. (Department: 2881)
Radiant energy
Ionic separation or analysis
Methods
C702S030000
Reexamination Certificate
active
11173937
ABSTRACT:
High-intensity, spiked noise is reduced in chromatography-mass spectrometry data by applying a nonlinear filter such as a moving median filter to the data. The filter is applied to individual mass chromatograms, plots of ion abundance versus retention time for each detected mass-to-charge ratio, and the filtered chromatograms are combined to form a filtered total ion current chromatogram. Standard linear filters are not effective for reducing noise in liquid chromatography-mass spectrometry (LC-MS) data because they assume a normal distribution of noise. LC-MS noise, however, is not normally distributed.
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Nguyen Kiet T.
PPD Biomarker Discovery Sciences LLC
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