Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-03-11
1994-10-11
Bhat, Nina
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436 57, 436161, 436504, 436536, 436542, C12Q 100, G01N 3353
Patent
active
053546628
ABSTRACT:
A method for determining the quantity of a connective tissue or muscle tissue breakdown product in a body fluid from an animal includes steps of providing a standard comprising the breakdown product having a label, the standard having a known specific activity, combining the standard and a sample of the body fluid, removing from the combined standard and sample a purified breakdown product fraction containing labelled breakdown product from the standard together with breakdown product from the sample, and measuring the specific radioactivity of the fraction as a measure of the quantity of the breakdown product in the sample. Also, methods for assessing, in a body fluid from an animal, the condition of a selected connective tissue or a muscle tissue in an animal, and for assessing a disease process that includes destruction of a specified connective tissue component or muscle tissue, and for assessing the efficacy of a therapy for treatment of such a disease process, include the steps of the method for determining the quantity of a tissue breakdown product.
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Franzblau Carl
Stone Phillip J.
Bhat Nina
Trustees of Boston University
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