Chemistry: analytical and immunological testing – Including use of radioactive properties
Patent
1990-05-15
1993-06-08
Housel, James C.
Chemistry: analytical and immunological testing
Including use of radioactive properties
436161, 436174, 422 70, G01N 2300, G01N 2306, G01N 3002, B01D 1503
Patent
active
052179036
ABSTRACT:
A method for determining a connective tissue breakdown product in a body fluid from an animal includes steps of providing a standard comprising the breakdown product having a radioactive label, the standard having a known specific radioactivity, combining the standard and a sample of the body fluid, removing from the combined standard and sample a purified breakdown product fraction containing labelled breakdown product from the standard together with breakdown product from the sample, and measuring the specific radioactivity of the fraction as a measure of the quantity of the breakdown product in the sample. Also, methods for assessing a condition of a selected connective tissue in an animal in vivo, and for assessing in vivo a disease process that includes destruction of a specified connective tissue component, and for assessing in vivo the efficacy of a therapy for treatment of such a disease process, include the steps of the method for determining a connective tissue breakdown product.
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This invention was made in the course of work supported in part by funds provided by the U.S. Government, and the Government has certain rights in the invention.
Bryan-Rhadfi Julianne
Franzblau Carl
Stone Phillip J.
Bhat N.
Housel James C.
Trustees of Boston University
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