Measurements of multiple molecules using a CryoArray

Details Measurements of multiple molecules using a CryoArray Measurements of multiple molecules using a CryoArray

2005-10-04

2005-10-04

Gitomer, Ralph (Department: 1651)

Chemistry: analytical and immunological testing

Including sample preparation

C436S008000, C436S063000, C435S001100, C435S004000, C435S005000, C435S006120, C435S007100, C435S040500, C435S091100, C435S307100, C435S810000

Reexamination Certificate

active

06951761

ABSTRACT:
This disclosure relates to CryoArrays, which permit the analysis of samples (such as protein, nucleic acid, virus, or cell samples) in arrays that are prepared at low temperatures. Because CryoArrays are constructed as a block of substantially columnar samples, the block can be sliced to provide a plurality of identical or substantially identical individual arrays. The individual arrays can be used for parallel analysis of the same array feature set, for instance with different probes or under different conditions. Also provided are methods of making CryoArrays, devices for making CryoArrays, and kits.

REFERENCES:
patent: 5290706 (1994-03-01), Camiener
patent: 5382511 (1995-01-01), Stapleton
patent: 5416029 (1995-05-01), Miller et al.
patent: 5763170 (1998-06-01), Raybuck
patent: 5948621 (1999-09-01), Turner et al.
patent: 10248599 (1998-09-01), None
patent: WO 99/44062 (1999-09-01), None
patent: WO 99/44063 (1999-09-01), None
patent: WO 01/18238 (2001-03-01), None
patent: WO 01/34842 (2001-05-01), None
Arenkov et al., “Protein Microchips: Use for Immunoassay and Enzymatic Reactions,”Anal. Biochem.278:123-131, 2000.
Bowtell, “Options availabe-from start to finish-for obtaining expression data by microarray,”Nat. Genet.21:25-32, Jan. 1999.
Christendat et al., “Structural proteomics of an archaeon,”Nat. Struct. Biol.7(10):903-909, Oct. 2000.
Emili and Cagney, “Large-scale functional analysis using peptide or protein arrays,”Nat. Biotech.18:393-397, Apr. 2000.
Feng, “A protein microarray,”Nat. Struct. Biol.7(10):829, Oct. 2000.
Guschin et al., “Manual Manufacturing of Oligonucleotide, DNA and Protein Microchips,”Anal. Biochem.250:203-211, 1997.
Karow, “Spotted Arrays, Meet Sushi Arrays: Low Cost Gives Manufacturers Taste for These Chips,”BioArray News2(24):1 and 7, Jun. 14, 2002.
Karow, “Making Cheaper Alternatives to Spotted Arrays, Researchers Try Them Sushi Style,”ProteoMonitorpp. 6-7, Jun. 17, 2002.
Lander, “Array of hope,”Nat. Genet.21:3-4, Jan. 1999.
Liotta and Petricoin, “Beyond the genome to tissue proteomics,”Breast Cancer Res.2:13-14, 1999.
Maxwell and Davis, “Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines,”PNAS97(24):13009-13014, Nov. 21, 2000.
MacBeath and Schreiber, “Printing Proteins as Microarrays for High-Throughput Function Determination,”Science289:1760-1763, Sep. 8, 2000.
A.S., “Cheap Chips, NIDDK,”Genome Technologypp. 54 and 56, Jul. 2002.
Schreiber, “Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery,”Science287:1964-1969, Mar. 17, 2000.
Zhu et al., “Analysis of yeast protein kinases using protein chips,”Nat. Genet.26(3):283-289, Nov. 2000.
Zhu et al., “Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays,”Proc. Natl. Acad. Sci. USA95:14470-14475, Nov. 1998.
Zhu and Snyder, “Protein arrays and microarrays,”Curr. Opin. Chem. Biol.5:40-45, 2001.
MacBeath and Koehler, “Experimental Procedures for Small Molecule Printing,” http://www-schreiber.chem.harvard.edu/home/protocols/SMP_text.html, Aug. 11, 1999 (11 pages).
“Genome Wonderland Gives Way to Daunting Challenges of the Proteome,”Howard Hughes Medical Institute—Newshttp://www.hhmi.org
ews/fields2.html, Feb. 11, 2001 (4 pages).
“Genomic Analysis of Protein Function,”Howard Hughes Medical Institute—In the Labhttp://www.hhmi.org/research/investigators/fields.html, Feb. 11, 2001 (3 pages).
“Protein Chips Offer Powerful Method for Probing Protein Function,”Howard Hughes Medical Institute—Newshttp://www.hhmi.org
ews/schreiber.html, Sep. 8, 2000 (3 pages).
“Chemical Genetics,”Howard Hughes Medical Institute—In the Labhttp://www.hhmi.org/research/investigators/schreiber.html, Dec. 27, 2000 (3 pages).
“ ‘Protein chips’ offer powerful method for probing protein function,”EurekAlerthttp://www.eurekalert.org/releases/hhmi-pco090600.html, Sep. 8, 2000 (2 pages).
Miyaji et al., “CryoArray, a new platform for proteomics on recombinant and native proteins,”2001 ASN/ISN World Congress of NephrologyDATE (5 pages including schedule).

Affiliated with

Also associated with

Rating

Measurements of multiple molecules using a CryoArray does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Measurements of multiple molecules using a CryoArray, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Measurements of multiple molecules using a CryoArray will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3478013