Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Reexamination Certificate
2006-02-21
2006-02-21
Lankford, Jr., Leon B. (Department: 1651)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
C424S600000, C435S004000
Reexamination Certificate
active
07001587
ABSTRACT:
Provided herein are methods for measuring protein biosynthesis by using2H2O or radioactive3H2O and applicable uses thereof.
REFERENCES:
patent: 4332784 (1982-06-01), Smith et al.
patent: 5338686 (1994-08-01), Hellerstein
patent: 5439803 (1995-08-01), Ross et al.
patent: 5910403 (1999-06-01), Hellerstein
patent: 5961470 (1999-10-01), Wagner et al.
patent: 6010846 (2000-01-01), Hellerstein
patent: 6461806 (2002-10-01), Hellerstein
patent: 6461870 (2002-10-01), Yatscoff et al.
patent: 6468802 (2002-10-01), Yatscoff et al.
patent: 6599750 (2003-07-01), Yatscoff et al.
patent: 6602715 (2003-08-01), Yatscoff et al.
patent: 6653076 (2003-11-01), Franza, Jr. et al.
patent: 6653090 (2003-11-01), Lopaschuk
patent: 6808875 (2004-10-01), Hellerstein
patent: 2003/0133871 (2003-07-01), Hellerstein
patent: 2003/0148533 (2003-08-01), Malloy et al.
patent: 2003/0180710 (2003-09-01), Lee et al.
patent: 2003/0180800 (2003-09-01), Lee et al.
patent: 2003/0224420 (2003-12-01), Hellerstein
patent: 2003/0228259 (2003-12-01), Hellerstein
patent: 2004/0081994 (2004-04-01), Hellerstein
patent: 2004/0091943 (2004-05-01), Schneider
patent: 2004/0115131 (2004-06-01), Hellerstein
patent: 2004/0152994 (2004-08-01), Meier-Augenstein
patent: 2004/0253647 (2004-12-01), Mathews et al.
patent: 2005/0019251 (2005-01-01), Hellerstein
patent: 2005/0053992 (2005-03-01), Hellerstein
patent: 2005/0147558 (2005-07-01), Hellerstein
patent: WO-90/11371 (1990-10-01), None
patent: WO-93/25705 (1993-12-01), None
patent: WO 98/51820 (1998-11-01), None
patent: WO-03/061479 (2003-07-01), None
patent: WO-03/068919 (2003-08-01), None
patent: WO-03/087314 (2003-10-01), None
patent: WO-04/003493 (2004-01-01), None
patent: WO-04/011426 (2004-02-01), None
patent: WO-04/021863 (2004-03-01), None
patent: WO-04/024941 (2004-03-01), None
patent: WO-04/025270 (2004-03-01), None
patent: WO-04/042360 (2004-05-01), None
patent: WO-05/009597 (2005-02-01), None
patent: WO-05/015155 (2005-02-01), None
patent: WO-05/033652 (2005-04-01), None
Jones et al., “Interaction of Dietary Fat Saturation and Cholesterol Level on Cholesterol Synthesis Measured Using Deuterium Incorporation”, Journal of Lipid Research, vol. 35, 1994, pp. 1093-1101.
Ajie et al., “In Vivo Study of the Biosynthesis of Long Chain Fatty Acids Using Deuterium Water”, Am J Physiology, 1995, 269 (2 Pt 1):E247-52.
U.S. Appl. No. 10/155,536, filed May 24, 2002, Hellerstein.
Airhart, J., A. Vidrich, and E. A. Khairallah. Compartmentation of free amino acids for protein synthesis in rat liver.Biochem J140: 539-45, 1974.
Bonotto, S., I. Ndoite, G. Nuyts, E. Fagniart, and R. Kirchmon. Study of the distribution and biological effects of3H in the Algae Acetabularia, Chlamydomonas and Porphyra.Curr Top Rad Quart12: 115-132, 1977.
Chinkes, D. L., A. Aarsland, J. Rosenblatt, and R. R. Wolfe. Comparison of mass isotopomer dilution methods used to calculate VLDL production in vivo.Am. J. Physiol. 271 (Endocrinol. Metab. 34): E373-E383, 1996.
Conrads, Thomas P. and Timothy D. Veenstra. Stable Isotope Labeling in ProteomicsThe Synthesis Cambridge Isotope Laboratories3 (2): 1-3, Jan. 2002.
Etnier, E., C. Travis, and D. Hetrick. Metabolism of organically bound tritium in man.Rad Res100: 487-502, 1984.
Hellerstein, Marc K. et al. Measurement of synthesis rates of slow-turnover proteins from2H2O incorporation into non-essential amino acids (NEAA) and application of mass isotopomer distribution analysis (MIDA).Faseb Journal Experimental Biology 2002: Meeting Abstracts16: pp A256, 2002.
Hellerstein, M. K., and R. A. Neese. Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations.Am J Physiol276: E1146-70, 1999.
Hellerstein, M. K., and R. A. Neese. Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers.Am J Physiol263: E988-1001, 1992.
Hellerstein, M. K. Methods for measurement of fatty acid and cholesterol metabolism.Current Opinion in Lipidology6: 172-181, 1995.
Humphrey, T., and D. Davies, A new method for the measurement of protein turnover.Biochem J148: 119-127, 1975.
Humphrey, T., and D. Davies. A sensitive method for measuring protein turnover based on the measurement of 2-3H-labeled amino acids in proteins.Biochem J156: 561-568, 1976.
Jungas, R. L. Fatty acid synthesis in adipose tissue incubated in tritiated water.Biochemistry7: 3708-17, 1968.
Katz, J., and R. Rognstad. Futile cycles in the metabolism of glucose.Curr Top Cell Regul10: 237-89, 1976.
Kelleher, J. K., and T. M. Masterson. Model equations for condensation biosynthesis using stable isotopes and radioisotopes.Am. J. Physiol. 262 (Endocrinol. Metab. 25): E118-E125, 1992.
Khairallah, E. A., and G. E. Mortimore. Assessment of protein turnover in perfused rat liver. Evidence for amino acid compartmentation from differential labeling of free and tRNA-gound valine.J Biol Chem251: 1375-84, 1976.
Kim, J. et al. “A New Stable Isotope-Mass Spectrometric (MS) Method to Measure Proliferation Rates of Colon Epithelial Cells”Faseb Journal14 (4): pp A718, 2000.
Mathur-De vré, R., and J. Binet. Molecular aspects of tritiated water and natural water in radiation biology,Prog Biophys Molec Biol43: 161-193, 1984.
Mewissen, D., M. Furedi, A. Ugarte, and J. Rust. Comparative incorporation of tritium from tritiated water vs tritiated thymidine, uridine or leucine.Curr Top Rad Res Quart12: 225-254, 1977.
Papageorgopoulos, Christina et al. Measuring Protein Synthesis by Mass Isotopomer Distribution Analysis (MIDA)Analytical Biochemistry267: 1-16, 1999.
Patterson, B. W., and R. R. Wolfe. Concentration dependence of methyl-palmitate isotope ratios by electron impact ionization gas chromatography/mass spectrometry.Biol. Mass Spectrom. 22: 481-486, 1993.
Previs, Stephen F. et al. Estimation of Protein Turnover In Vivo Using D2O.Diabetes Abstract Book, 61st Scientific Sessions, vol. 50 Supplement 2: A301, Jun. 2001.
van Hinsbergh, V.W.M., et al. Palmitate Oxidation by Rat Skeletal Muscle Mitochondria,Archives of Biochemistry and Biophysics190 (2): 762-771, 1978.
Veerkamp, Jacques H. et al.14CO2Production Is No Adequate Measure of [14C]Fatty Acid Oxidation.Biochem Medicine and Metabolic Biology35: 248-259 (1986).
Bingham, SA (Jan. 1994) “The use of 24-h urine samples and energy expenditure to validate dietary assessments”American Journal of Clinical Nutrition59 (1 suppl): pp. 227S-231S.
Craig, SB et al. (Sep. 1996) “The Impact of Physical Activity on Lipids, Lipoproteins, and Blood Pressure in Preadolescent Girls”Pediatrics(3 Pt 1): pp. 389-395.
McCune, Joseph M. et al. “Factors Influencing T-Cell Turnover in HIV-1-Seropositive Patients.”The Journal of Clinical Investigation 105:R1-R8, Oct. 1999.
Christiansen Mark P. et al. “Effect of Dietary Energy Restriction on Glucose Production and Substrate Utilization in Type 2 Diabetes.”Diabetes49: 1691-1699, Oct. 2000.
Wang, Wei et al. “Effects of Nicotinic Acid on Fatty Acid Kinetics, Fuel Selection, and Pathways of Glucose Production in Women.”Am. J. Physiol. Endocrinol. Metab. 279: E50-E59, 2000.
Parks, Elizabeth J. et al. “Carbohydrate-induced Hypertriacylglycerolemia: Historical Perspective and Review of Biological Mechanisms.”Am. J. Nutr. 2000; 71:412-433.
Leung, Gordon K. et al. “A Deficiency of Microsomal Triglyceride Transfer Protein Reduces Apolipoprotein B Secretion.”The Journal of Biological Chemistry275, No. 11:7515-7520, 2000.
Hudgins, Lisa C. et al. “Relationship Between Carbohydrate-Induced Hypertriglyceridemia and Fatty Synthesis in Lean and Obese Subjects.”Journal of Lipid Research41:595-604, 2000.
Davis, Ajuah et al. “Effect of Pinitol Treatment on Insulin Action in Subjects With Insulin Resistance.”Diabetes Care23, No. 23:1000-1005, 2000.
Lammert, Ole et al. “Effects of Isoenergetic Overfeeding of Either Carbohydrate or Fat in Young Men.”British Journal of Nutrition84:233-245, 2000.
Parks, Elizabeth J. et al. “D
Barnhart Lora E
Lankford , Jr. Leon B.
Morrison & Foerster / LLP
The Regents of the University of California
LandOfFree
Measurement of protein synthesis rates in humans and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Measurement of protein synthesis rates in humans and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Measurement of protein synthesis rates in humans and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3666143