Measurement of concentrations and binding energetics

Details Measurement of concentrations and binding energetics Measurement of concentrations and binding energetics

2008-06-16

2010-11-23

Gabel, Gailene R (Department: 1641)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C436S147000, C436S164000, C436S535000, C422S051000, C422S068100

Reexamination Certificate

active

07838284

ABSTRACT:
Free-standing microfluidic channels are used to both transport and analyze molecules of interest. In a biochemical context, such molecules may be polypeptides, nucleic acids, or other biomolecules. The free-standing channels provide a real-time readout of concentration without the need for labeling with reporter molecules. The channels can also measure enthalpy values and equilibrium constants by detecting heat released from or absorbed by the sample.

REFERENCES:
patent: 6477901 (2002-11-01), Tadigadapa et al.
patent: 7282329 (2007-10-01), Manalis et al.
Yang et al. “Mechanical behavior of ultrathin microcantilever” Sensors and Actuators A: Physical vol. 82, Issues 1-3, May 15, 2000, pp. 102-107.

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