Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Patent
1994-06-17
1997-02-04
Woodward, Michael P.
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
436172, 436518, 436528, 436532, 436546, 436810, 435 71, 435 78, 4353091, 435805, G01N 33566, G01N 2176, G01N 33543, G01N 3353
Patent
active
055997201
ABSTRACT:
A method of measuring the ambient concentration in a fluid, especially a body fluid, of an analyte, such as a hormone or other biologically active material, whose concentration in the fluid is dependent on thedilution of the fluid is disclosed. The fluid is contacted with a trace amount of a binding agent, such as an antibody, specific for the analyte, the proportional occupancy of binding sites on the binding agent is determined and from that figure the analyte concentration is estimated without the need to measure accurately beforehand the volume of the fluid or fluid sample being tested. It is therefore possible to design a concentration-measuring device for insertion into a body fluid of a living creature for in situ measurement of concentration.
REFERENCES:
patent: 4108974 (1978-08-01), Wegfahrt et al.
patent: 4256724 (1981-03-01), Rutner et al.
patent: 4299916 (1981-11-01), Litman et al.
patent: 4315907 (1982-02-01), Fridlender et al.
patent: 4381291 (1983-04-01), Ekins
patent: 4438067 (1984-03-01), Siddigi
patent: 4444880 (1984-04-01), Tom
patent: 4698298 (1987-10-01), Dedieu et al.
patent: 4842995 (1989-06-01), Iaccheri et al.
patent: 4853325 (1989-08-01), Vodian
patent: 5171695 (1992-12-01), Ekins
Ekins, R. P. et al, J. Endocrinol., 85(2)(1980), pp. 29P-30P.
Han, R et al, Radiol. Iugosl., 15(3) (1981), pp. 379-382.
Nisonoff et al, 1958. Heterogeneity and average combining constants of antibodies from individual rabbits. J Immunol. 80:417-28.
Pinckard, 1978. "Equilibruim dialysis and preparation of hapten conjugates" in Handbook of Experimental Immunology. vol. 1. Immunochemistry, (D. M. Weir, ed). Blackwell Scientific Publications, Oxford pp. 17.1-17.23.
Multilyte Limited
Woodward Michael P.
LandOfFree
Measurement of analyte concentration does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Measurement of analyte concentration, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Measurement of analyte concentration will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-677893