Measurement of an enzyme marker as an aid to diagnosis of liver

Details Measurement of an enzyme marker as an aid to diagnosis of liver Measurement of an enzyme marker as an aid to diagnosis of liver

1992-05-01

1993-06-08

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 15, C12Q 148

Patent

active

052178684

ABSTRACT:
A method which assists in the early diagnosis of rejection in a liver transplant recipient comprises measuring an increase in plasma or serum alpha glutathione S-tranferase (.alpha.-GST) from said recipient in the absence of or preceding any change in plasma or serum transaminase. .alpha.-GST is most suitably measured by enzymeimmunoassay, using a solid phase antibody which is monospecific for .alpha.-GST. The monospecific antibody cross-reacts with the .alpha.-GST dimers B.sub.1 B.sub.1, B.sub.1 B.sub.2 and B.sub.2 B.sub.2.

REFERENCES:
Calne, "Diagnosis of Rejection", (2d edition), pp. 301-303.
Hussey et al., Br. J. Anaesth. 60: 130-135 (1988).
Hayes et al., Clin. Chim. Acta. 172: 211-216 (1988).
Beckett et al., Clin. Chem. 35(6): 995-999 (1989).
Boss et al., Gastroenterology 74(4): 859-594 (1978).
Sherman et al., Hepatology 3(2): 162-169 (1983).
Haley et al., Biochem. J. 254: 255-259 (1988).
Beckett et al., Clin. Chem. 35: 2186-2189 (1989).

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