Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-10-05
1997-01-07
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 794, 435 15, C12Q 148
Patent
active
RE0354198
ABSTRACT:
A method which assists in the early diagnosis of rejection in a liver transplant recipient comprises measuring an increase in plasma or serum alpha glutathione S-[tranferase]transferase(.alpha.-GST) from said recipient in the absence of or preceding any change in plasma or serum transaminase. .alpha.-GST is most suitably measured by enzymeimmunoassay, using a solid phase antibody which is monospecific for .alpha.-GST. The monospecific antibody cross-reacts with the .alpha.-GST dimers B.sub.1 B.sub.1, B.sub.1 B.sub.2 and B.sub.2 B.sub.2.
REFERENCES:
Calne, Liver Transplantation (2d Edition), 1987, pp. 301-303.
Hussey et al., Br. J. Anaesth., 60, 130-133 (1988).
Hayes et al., Clin. Chim. Acta, 172, 211-216 (1988).
Beckett et al., Clin. Chem., 35(6), 995-999 (1989).
Boss et al., Gastroenterology, 74(4), 859-594 (1978).
Sherman et al., Hepatology, 3(2), 162-169 (1983).
Haley et al., Biochem J., 254, 255-259 (1988).
Beckett et al., Clin. Chem., 35, 2186-2189 (1989).
Kilty Cormac G.
O'Byrne Seamus
Kilty Cormac G.
O'Byrne Seamus
Saunders David
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