Measurement and use of molecular interactions

Details Measurement and use of molecular interactions Measurement and use of molecular interactions

2007-03-27

2007-03-27

Chin, Christopher L. (Department: 1641)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C422S051000, C422S082050, C435S005000, C435S006120, C435S007200, C435S007320, C435S288700, C435S808000, C436S518000, C436S524000, C436S527000, C436S164000, C436S805000, C310S311000, C310S312000, C310S31300R, C310S340000

Reexamination Certificate

active

10350892

ABSTRACT:
The subject invention pertains to a method for determining the affinity between binding partners, or a property of one of the binding partners dependent on the affinity, comprising the steps of:(i) contacting the binding partners, one of which is immobilised on a surface;(ii) oscillating the surface at increasing amplitude; and(iii) detecting a dissociation event.An analogous method can be used to separate a target analyte from a composition. The subject invention also pertains to an apparatus for determining the affinity between binding partners, and comprises: a surface (10) having one binding partner (16) immobilised thereon; means for oscillating the surface at increasing amplitude; and means (14, 15) for detecting a dissociation event.

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